Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)
1_MSKQQ 6_ PTQFI 11_ NPETP 16_ GYVGF 21_ ANLPN 26_ QVHRK 31_ SVKKG 36_ FEFTL 41_ MVVGE 46_ SGLGK 51_ STLIN 56_ SLFLT 61_ DLYPE 66_ RVIPG 71_ AAEKI 76_ ERTVQ 81_ IEAST 86_ VEIEE 91_ RGVKL 96_ RLTVV 101_ DTPGY 106_ GDAIN 111_ CRDCF 116_ KTIIS 121_ YIDEQ 126_ FERYL 131_ HDESG 136_ LNRRH 141_ IIDNR 146_ VHCCF 151_ YFISP 156_ FGHGL 161_ KPLDV 166_ AFMKA 171_ IHNKV 176_ NIVPV 181_ IAKAD 186_ TLTLK 191_ ERERL 196_ KKRIL 201_ DEIEE 206_ HNIKI 211_ YHLPD 216_ AESDE 221_ DEDFK 226_ EQTRL 231_ LKASI 236_ PFSVV 241_ GSNQL 246_ IEAKG 251_ KKVRG 256_ RLYPW 261_ GVVEV 266_ ENPEH 271_ NDFLK 276_ LRTML 281_ ITHMQ 286_ DLQEV 291_ TQDLH 296_ YENFR 301_ SERLK 306_ RGGRK 311_ VENED 316_ MNKDQ 321_ ILLEK 326_ EAELR 331_ RMQEM 336_ IARMQ 341_ AQMQM 346_ QMQGG 351_ DGDGG 356_ALGHH
1: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri