Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)
1_MATAA 6_ ETSAS 11_ EPEAE 16_ SKAGP 21_ KADGE 26_ EDEVK 31_ AARTR 36_ RKVLS 41_ RAVAA 46_ ATYKT 51_ MGPAW 56_ DQQEE 61_ GVSES 66_ DGDEY 71_ AMASS 76_ AESSP 81_ GEYEW 86_ EYDEE 91_ EEKNQ 96_ LEIER 101_ LEEQL 106_ SINVY 111_ DYNCH 116_ VDLIR 121_ LLRLE 126_ GELTK 131_ VRMAR 136_ QKMSE 141_ IFPLT 146_ EELWL 151_ EWLHD 156_ EISMA 161_ QDGLD 166_ REHVY 171_ DLFEK 176_ AVKDY 181_ ICPNI 186_ WLEYG 191_ QYSVG 196_ GIGQK 201_ GGLEK 206_ VRSVF 211_ ERALS 216_ SVGLH 221_ MTKGL 226_ ALWEA 231_ YREFE 236_ SAIVE 241_ AARLE 246_ KVHSL 251_ FRRQL 256_ AIPLY 261_ DMEAT 266_ FAEYE 271_ EWSED 276_ PIPES 281_ VIQNY 286_ NKALQ 291_ QLEKY 296_ KPYEE 301_ ALLQA 306_ EAPRL 311_ AEYQA 316_ YIDFE 321_ MKIGD 326_ PARIQ 331_ LIFER 336_ ALVEN 341_ CLVPD 346_ LWIRY 351_ SQYLD 356_ RQLKV 361_ KDLVL 366_ SVHNR 371_ AIRNC 376_ PWTVA 381_ LWSRY 386_ LLAME 391_ RHGVD 396_ HQVIS 401_ VTFEK 406_ ALNAG 411_ FIQAT 416_ DYVEI 421_ WQAYL 426_ DYLRR 431_ RVDFK 436_ QDSSK 441_ ELEEL 446_ RAAFT 451_ RALEY 456_ LKQEV 461_ EERFN 466_ ESGDP 471_ SCVIM 476_ QNWAR 481_ IEARL 486_ CNNMQ 491_ KAREL 496_ WDSIM 501_ TRGNA 506_ KYANM 511_ WLEYY 516_ NLERA 521_ HGDTQ 526_ HCRKA 531_ LHRAV 536_ QCTSD 541_ YPEHV 546_ CEVLL 551_ TMERT 556_ EGSLE 561_ DWDIA 566_ VQKTE 571_ TRLAR 576_ VNEQR 581_ MKAAE 586_ KEAAL 591_ VQQEE 596_ EKAEQ 601_ RKRAR 606_ AEKKA 611_ LKKKK 616_ KIRGP 621_ EKRGA 626_ DEDDE 631_ KEWGD 636_ DEEEQ 641_ PSKRR 646_ RVENS 651_ IPAAG 656_ ETQNV 661_ EVAAG 666_ PAGKC 671_ AAVDV 676_ EPPSK 681_ QKEKA 686_ ASLKR 691_ DMPKV 696_ LHDSS 701_ KDSIT 706_ VFVSN 711_ LPYSM 716_ QEPDT 721_ KLRPL 726_ FEACG 731_ EVVQI 736_ RPIFS 741_ NRGDF 746_ RGYCY 751_ VEFKE 756_ EKSAL 761_ QALEM 766_ DRKSV 771_ EGRPM 776_ FVSPC 781_ VDKSK 786_ NPDFK 791_ VFRYS 796_ TSLEK 801_ HKLFI 806_ SGLPF 811_ SCTKE 816_ ELEEI 821_ CKAHG 826_ TVKDL 831_ RLVTN 836_ RAGKP 841_ KGLAY 846_ VEYEN 851_ ESQAS 856_ QAVMK 861_ MDGMT 866_ IKENI 871_ IKVAI 876_ SNPPQ 881_ RKVPE 886_ KPETR 891_ KAPGG 896_ PMLLP 901_ QTYGA 906_ RGKGR 911_ TQLSL 916_ LPRAL 921_ QRPSA 926_ AAPQA 931_ ENGPA 936_ AAPAV 941_ AAPAA 946_ TEAPK 951_ MSNAD 956_FAKLF
1: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity)
2: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication