Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)
1_MAPQK 6_ HGGGG 11_ GGGSG 16_ PSAGS 21_ GGGGF 26_ GGSAA 31_ VAAAT 36_ ASGGK 41_ SGGGS 46_ CGGGG 51_ SYSAS 56_ SSSSA 61_ AAAAG 66_ AAVLP 71_ VKKPK 76_ MEHVQ 81_ ADHEL 86_ FLQAF 91_ EKPTQ 96_ IYRFL 101_ RTRNL 106_ IAPIF 111_ LHRTL 116_ TYMSH 121_ RNSRT 126_ NIKRK 131_ TFKVD 136_ DMLSK 141_ VEKMK 146_ GEQES 151_ HSLSA 156_ HLQLT 161_ FTGFF 166_ HKNDK 171_ PSPNS 176_ ENEQN 181_ SVTLE 186_ VLLVK 191_ VCHKK 196_ RKDVS 201_ CPIRQ 206_ VPTGK 211_ KQVPL 216_ NPDLN 221_ QTKPG 226_ NFPSL 231_ AVSSN 236_ EFEPS 241_ NSHMV 246_ KSYSL 251_ LFRVT 256_ RPGRR 261_ EFNGM 266_ INGET 271_ NENID 276_ VNEEL 281_ PARRK 286_ RNRED 291_ GEKTF 296_ VAQMT 301_ VFDKN 306_ RRLQL 311_ LDGEY 316_ EVAMQ 321_ EMEEC 326_ PISKK 331_ RATWE 336_ TILDG 341_ KRLPP 346_ FETFS 351_ QGPTL 356_ QFTLR 361_ WTGET 366_ NDKST 371_ APIAK 376_ PLATR 381_ NSESL 386_ HQENK 391_ PGSVK 396_ PTQTI 401_ AVKES 406_ LTTDL 411_ QTRKE 416_ KDTPN 421_ ENRQK 426_ LRIFY 431_ QFLYN 436_ NNTRQ 441_ QTEAR 446_ DDLHC 451_ PWCTL 456_ NCRKL 461_ YSLLK 466_ HLKLC 471_ HSRFI 476_ FNYVY 481_ HPKGA 486_ RIDVS 491_ INECY 496_ DGSYA 501_ GNPQD 506_ IHRQP 511_ GFAFS 516_ RNGPV 521_ KRTPI 526_ THILV 531_ CRPKR 536_ TKASM 541_ SEFLE 546_ SEDGE 551_ VEQQR 556_ TYSSG 561_ HNRLY 566_ FHSDT 571_ CLPLR 576_ PQEME 581_ VDSED 586_ EKDPE 591_ WLREK 596_ TITQI 601_ EEFSD 606_ VNEGE 611_ KEVMK 616_ LWNLH 621_ VMKHG 626_ FIADN 631_ QMNHA 636_ CMLFV 641_ ENYGQ 646_ KIIKK 651_ NLCRN 656_ FMLHL 661_ VSMHD 666_ FNLIS 671_ IMSID 676_ KAVTK 681_ LREMQ 686_ QKLEK 691_ GESAS 696_ PANEE 701_ ITEEQ 706_ NGTAN 711_ GFSEI 716_ NSKEK 721_ ALETD 726_ SVSGV 731_SKQSK
1: Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557)