Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8)
1_MASVT 6_ LSEAE 11_ KVYIV 16_ HGVQE 21_ DLRVD 26_ GRGCE 31_ DYRCV 36_ EVETD 41_ VVSNT 46_ SGSAR 51_ VKLGH 56_ TDILV 61_ GVKAE 66_ MGTPK 71_ LEKPN 76_ EGYLE 81_ FFVDC 86_ SASAT 91_ PEFEG 96_ RGGDD 101_ LGTEI 106_ ANTLY 111_ RIFNN 116_ KSSVD 121_ LKTLC 126_ ISPRE 131_ HCWVL 136_ YVDVL 141_ LLECG 146_ GNLFD 151_ AISIA 156_ VKAAL 161_ FNTRI 166_ PRVRV 171_ LEDEE 176_ GSKDI 181_ ELSDD 186_ PYDCI 191_ RLSVE 196_ NVPCI 201_ VTLCK 206_ IGYRH 211_ VVDAT 216_ LQEEA 221_ CSLAS 226_ LLVSV 231_ TSKGV 236_ VTCMR 241_ KVGKG 246_ SLDPE 251_ SIFEM 256_ METGK 261_ RVGKV 266_ LHASL 271_ QSVVH 276_ KEESL 281_ GPKRQ 286_KVGFL
1: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes