TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
1_MEGRG 6_ PYRIY 11_ DPGGS 16_ VPSGE 21_ ASAAF 26_ ERLVK 31_ ENSRL 36_ KEKMQ 41_ GIKML 46_ GELLE 51_ ESQME 56_ ATRLR 61_ QKAEE 66_ LVKDN 71_ ELLPP 76_ PSPSL 81_ GSFDP 86_ LAELT 91_ GKDSN 96_ VTASP 101_ TAPAC 106_ PSDKP 111_ APVQK 116_ PPSSG 121_ TSSEF 126_ EVVTP 131_ EEQNS 136_ PESSS 141_ HANAM 146_ ALGPL 151_ PREDG 156_ NLMLH 161_ LQRLE 166_ TTLSV 171_ CAEEP 176_ DHGQL 181_ FTHLG 186_ RMALE 191_ FNRLA 196_ SKVHK 201_ NEQRT 206_ SILQT 211_ LCEQL 216_ RKENE 221_ ALKAK 226_ LDKGL 231_ EQRDQ 236_ AAERL 241_ REENL 246_ ELKKL 251_ LMSNG 256_ NKEGA 261_ SGRPG 266_ SPKME 271_ GTGKK 276_ AVAGQ 281_ QQASV 286_ TAGKV 291_ PEVVA 296_ LGAAE 301_ KKVKM 306_ LEQQR 311_ SELLE 316_ VNKQW 321_ DQHFR 326_ SMKQQ 331_ YEQKI 336_ TELRQ 341_ KLADL 346_ QKQVT 351_ DLEAE 356_ REQKQ 361_ RDFDR 366_ KLLLA 371_ KSKIE 376_ MEETD 381_ KEQLT 386_ AEAKE 391_ LRQKV 396_ KYLQD 401_ QLSPL 406_ TRQRE 411_ YQEKE 416_ IQRLN 421_ KALEE 426_ ALSIQ 431_ TPPSS 436_ PPTAF 441_ GSPEG 446_ AGALL 451_ RKQEL 456_ VTQNE 461_ LLKQQ 466_ VKIFE 471_ EDFQR 476_ ERSDR 481_ ERMNE 486_ EKEEL 491_ KKQVE 496_ KLQAQ 501_ VTLSN 506_ AQLKA 511_ FKDEE 516_ KAREA 521_ LRQQK 526_ RKAKA 531_ SGERY 536_ HVEPH 541_ PEHLC 546_ GAYPY 551_ AYPPM 556_ PAMVP 561_ HHGFE 566_ DWSQI 571_ RYPPP 576_ PMAME 581_ HPPPL 586_ PNSRL 591_ FHLPE 596_ YTWRL 601_ PCGGV 606_ RNPNQ 611_ SSQVM 616_ DPPTA 621_ RPTEP 626_ ESPKN 631_DREGP
1: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (PubMed:21885437). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection