Sorting nexin-17
1_MHFSI 6_ PETES 11_ RSGDS 16_ GGSAY 21_ VAYNI 26_ HVNGV 31_ LHCRV 36_ RYSQL 41_ LGLHE 46_ QLRKE 51_ YGANV 56_ LPAFP 61_ PKKLF 66_ SLTPA 71_ EVEQR 76_ REQLE 81_ KYMQA 86_ VRQDP 91_ LLGSS 96_ ETFNS 101_ FLRRA 106_ QQETQ 111_ QVPTE 116_ EVSLE 121_ VLLSN 126_ GQKVL 131_ VNVLT 136_ SDQTE 141_ DVLEA 146_ VAAKL 151_ DLPDD 156_ LIGYF 161_ SLFLV 166_ REKED 171_ GAFSF 176_ VRKLQ 181_ EFELP 186_ YVSVT 191_ SLRSQ 196_ EYKIV 201_ LRKSY 206_ WDSAY 211_ DDDVM 216_ ENRVG 221_ LNLLY 226_ AQTVS 231_ DIERG 236_ WILVT 241_ KEQHR 246_ QLKSL 251_ QEKVS 256_ KKEFL 261_ RLAQT 266_ LRHYG 271_ YLRFD 276_ ACVAD 281_ FPEKD 286_ CPVVV 291_ SAGNS 296_ ELSLQ 301_ LRLPG 306_ QQLRE 311_ GSFRV 316_ TRMRC 321_ WRVTS 326_ SVPLP 331_ SGSTS 336_ SPGRG 341_ RGEVR 346_ LELAF 351_ EYLMS 356_ KDRLQ 361_ WVTIT 366_ SPQAI 371_ MMSIC 376_ LQSMV 381_ DELMV 386_ KKSGG 391_ SIRKM 396_ LRRRV 401_ GGTLR 406_ RSDSQ 411_ QAVKS 416_ PPLLE 421_ SPDAT 426_ RESMV 431_ KLSSK 436_ LSAVS 441_ LRGIG 446_ SPSTD 451_ ASASD 456_ VHGNF 461_AFEGI
1: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798)