Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)
1_MSCVP 6_ WKGDK 11_ AKSES 16_ LELPQ 21_ AAPPQ 26_ IYHEK 31_ QRREL 36_ CALHA 41_ LNNVF 46_ QDSNA 51_ FTRDT 56_ LQEIF 61_ QRLSP 66_ NTMVT 71_ PHKKS 76_ MLGNG 81_ NYDVN 86_ VIMAA 91_ LQTKG 96_ YEAVW 101_ WDKRR 106_ DVGVI 111_ ALTNV 116_ MGFIM 121_ NLPSS 126_ LCWGP 131_ LKLPL 136_ KRQHW 141_ ICVRE 146_ VGGAY 151_ YNLDS 156_ KLKMP 161_ EWIGG 166_ ESELR 171_ KFLKH 176_ HLRGK 181_ NCELL 186_ LVVPE 191_ EVEAH 196_QSWRT
1: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity