Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)
1_MAADS 6_ EPESE 11_ VFEIT 16_ DFTTA 21_ SEWER 26_ FISKV 31_ EEVLN 36_ DWKLI 41_ GNSLG 46_ KPLEK 51_ GIFTS 56_ GTWEE 61_ KSDEI 66_ SFADF 71_ KFSVT 76_ HHYLV 81_ QESTD 86_ KEGKD 91_ ELLED 96_ VVPQS 101_ MQDLL 106_ GMNND 111_ FPPRA 116_ HCLVR 121_ WYGLR 126_ EFVVI 131_ APAAH 136_ SDAVL 141_ SESKC 146_ NLLLS 151_ SVSIA 156_ LGNTG 161_ CQVPL 166_ FVQIH 171_ HKWRR 176_ MYVGE 181_ CQGPG 186_ VRTDF 191_ EMVHL 196_ RKVPN 201_ QYTHL 206_ SGLLD 211_ IFKSK 216_ IGCPL 221_ TPLPP 226_ VSIAI 231_ RFTYV 236_ LQDWQ 241_ QYFWP 246_ QQPPD 251_ IDALV 256_ GGEVG 261_ GLEFG 266_ KLPFG 271_ ACEDP 276_ ISELH 281_ LATTW 286_ PHLTE 291_ GIIVD 296_ NDVYS 301_ DLDPI 306_ QAPHW 311_ SVRVR 316_ KAENP 321_ QCLLG 326_ DFVTE 331_ FFKIC 336_ RRKES 341_ TDEIL 346_ GRSAF 351_ EEEGK 356_ ETADI 361_ THALS 366_ KLTEP 371_ ASVPI 376_ HKLSV 381_ SNMVH 386_ TAKKK 391_ IRKHR 396_ GVEES 401_ PLNND 406_ VLNTI 411_ LLFLF 416_ PDAVS 421_ EKPLD 426_ GTTST 431_ DNNNP 436_ PSESE 441_ DYNLY 446_ NQFKS 451_ APSDS 456_ LTYKL 461_ ALCLC 466_ MINFY 471_ HGGLK 476_ GVAHL 481_ WQEFV 486_ LEMRF 491_ RWENN 496_ FLIPG 501_ LASGP 506_ PDLRC 511_ CLLHQ 516_ KLQML 521_ NCCIE 526_ RKKAR 531_ DEGKK 536_ TSASD 541_ VTNIY 546_ PGDAG 551_ KAGDQ 556_ LVPDN 561_ LKETD 566_ KEKGE 571_ VGKSW 576_ DSWSD 581_ SEEEF 586_ FECLS 591_ DTEEL 596_ KGNGQ 601_ ESGKK 606_ GGPKE 611_ MANLR 616_ PEGRL 621_ YQHGK 626_ LTLLH 631_ NGEPL 636_ YIPVT 641_ QEPAP 646_ MTEDL 651_ LEEQS 656_ EVLAK 661_ LGTSA 666_ EGAHL 671_ RARMQ 676_ SACLL 681_ SDMES 686_ FKAAN 691_ PGCSL 696_ EDFVR 701_ WYSPR 706_ DYIEE 711_ EVIDE 716_ KGNVV 721_ LKGEL 726_ SARMK 731_ IPSNM 736_ WVEAW 741_ ETAKP 746_ IPARR 751_ QRRLF 756_ DDTRE 761_ AEKVL 766_ HYLAI 771_ QKPAD 776_ LARHL 781_ LPCVI 786_ HAAVL 791_ KVKEE 796_ ESLEN 801_ ISSVK 806_ KIIKQ 811_ IISHS 816_ SKVLH 821_ FPNPE 826_ DKKLE 831_ EIIHQ 836_ ITNVE 841_ ALIAR 846_ ARSLK 851_ AKFGT 856_ EKCEQ 861_ EEEKE 866_ DLERF 871_ VSCLL 876_ EQPEV 881_ LVTGA 886_ GRGHA 891_ GRIIH 896_ KLFVN 901_ AQRAA 906_ AMTPP 911_ EEELK 916_ RMGSP 921_ EERRQ 926_ NSVSD 931_ FPPPA 936_ GREFI 941_ LRTTV 946_ PRPAP 951_ YSKAL 956_ PQRMY 961_ SVLTK 966_ EDFRL 971_ AGAFS 976_SDTSF
1: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:10859313, PubMed:24891604, PubMed:9030515). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604). Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated (PubMed:26063829). Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604). Required for normal eye and brain development (PubMed:15696165, PubMed:23420520). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129)