Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
1_MKLLL 6_ LHPAF 11_ QSCLL 16_ LTLLG 21_ LWRTT 26_ PEAHA 31_ SSLGA 36_ PAISA 41_ ASFLQ 46_ DLIHR 51_ YGEGD 56_ SLTLQ 61_ QLKAL 66_ LNHLD 71_ VGVGR 76_ GNVTQ 81_ HVQGH 86_ RNLST 91_ CFSSG 96_ DLFTA 101_ HNFSE 106_ QSRIG 111_ SSELQ 116_ EFCPT 121_ ILQQL 126_ DSRAC 131_ TSENQ 136_ ENEEN 141_ EQTEE 146_ GRPSA 151_ VEVWG 156_ YGLLC 161_ VTVIS 166_ LCSLL 171_ GASVV 176_ PFMKK 181_ TFYKR 186_ LLLYF 191_ IALAI 196_ GTLYS 201_ NALFQ 206_ LIPEA 211_ FGFNP 216_ LEDYY 221_ VSKSA 226_ VVFGG 231_ FYLFF 236_ FTEKI 241_ LKILL 246_ KQKNE 251_ HHHGH 256_ SHYAS 261_ ESLPS 266_ KKDQE 271_ EGVME 276_ KLQNG 281_ DLDHM 286_ IPQHC 291_ SSELD 296_ GKAPM 301_ VDEKV 306_ IVGSL 311_ SVQDL 316_ QASQS 321_ ACYWL 326_ KGVRY 331_ SDIGT 336_ LAWMI 341_ TLSDG 346_ LHNFI 351_ DGLAI 356_ GASFT 361_ VSVFQ 366_ GISTS 371_ VAILC 376_ EEFPH 381_ ELGDF 386_ VILLN 391_ AGMSI 396_ QQALF 401_ FNFLS 406_ ACCCY 411_ LGLAF 416_ GILAG 421_ SHFSA 426_ NWIFA 431_ LAGGM 436_ FLYIS 441_ LADMF 446_ PEMNE 451_ VCQED 456_ ERKGS 461_ ILIPF 466_ IIQNL 471_ GLLTG 476_ FTIMV 481_ VLTMY 486_SGQIQ
1: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15642354, PubMed:27231142, PubMed:29621230). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010). Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174). Also involved in manganese extracellular uptake by cells of the blood-brain barrier (PubMed:31699897). May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781). Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (PubMed:23052185)