Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)
1_MAAVQ 6_ AAEVK 11_ VDGSE 16_ PKLSK 21_ NELKR 26_ RLKAE 31_ KKVAE 36_ KEAKQ 41_ KELSE 46_ KQLSQ 51_ ATAAA 56_ TNHTT 61_ DNGVG 66_ PEEES 71_ VDPNQ 76_ YYKIR 81_ SQAIH 86_ QLKVN 91_ GEDPY 96_ PHKFH 101_ VDISL 106_ TDFIQ 111_ KYSHL 116_ QPGDH 121_ LTDIT 126_ LKVAG 131_ RIHAK 136_ RASGG 141_ KLIFY 146_ DLRGE 151_ GVKLQ 156_ VMANS 161_ RNYKS 166_ EEEFI 171_ HINNK 176_ LRRGD 181_ IIGVQ 186_ GNPGK 191_ TKKGE 196_ LSIIP 201_ YEITL 206_ LSPCL 211_ HMLPH 216_ LHFGL 221_ KDKET 226_ RYRQR 231_ YLDLI 236_ LNDFV 241_ RQKFI 246_ IRSKI 251_ ITYIR 256_ SFLDE 261_ LGFLE 266_ IETPM 271_ MNIIP 276_ GGAVA 281_ KPFIT 286_ YHNEL 291_ DMNLY 296_ MRIAP 301_ ELYHK 306_ MLVVG 311_ GIDRV 316_ YEIGR 321_ QFRNE 326_ GIDLT 331_ HNPEF 336_ TTCEF 341_ YMAYA 346_ DYHDL 351_ MEITE 356_ KMVSG 361_ MVKHI 366_ TGSYK 371_ VTYHP 376_ DGPEG 381_ QAYDV 386_ DFTPP 391_ FRRIN 396_ MVEEL 401_ EKALG 406_ MKLPE 411_ TNLFE 416_ TEETR 421_ KILDD 426_ ICVAK 431_ AVECP 436_ PPRTT 441_ ARLLD 446_ KLVGE 451_ FLEVT 456_ CINPT 461_ FICDH 466_ PQIMS 471_ PLAKW 476_ HRSKE 481_ GLTER 486_ FELFV 491_ MKKEI 496_ CNAYT 501_ ELNDP 506_ MRQRQ 511_ LFEEQ 516_ AKAKA 521_ AGDDE 526_ AMFID 531_ ENFCT 536_ ALEYG 541_ LPPTA 546_ GWGMG 551_ IDRVA 556_ MFLTD 561_ SNNIK 566_ EVLLF 571_ PAMKP 576_ EDKKE 581_ NVATT 586_ DTLES 591_TTVGT
1: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:18029264, PubMed:18272479, PubMed:9278442). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:14975237, PubMed:19524539, PubMed:23159739, PubMed:5338216)
2: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation