Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
1_MSSLP 6_ GCIGL 11_ DAATA 16_ TVESE 21_ EIAEL 26_ QQAVV 31_ EELGI 36_ SMEEL 41_ RHFID 46_ EELEK 51_ MDCVQ 56_ QRKKQ 61_ LAELE 66_ TWVIQ 71_ KESEV 76_ AHVDQ 81_ LFDDA 86_ SRAVT 91_ NCESL 96_ VKDFY 101_ SKLGL 106_ QYRDS 111_ SSEDE 116_ SSRPT 121_ EIIEI 126_ PDEDD 131_ DVLSI 136_ DSGDA 141_ GSRTP 146_ KDQKL 151_ REAMA 156_ ALRKS 161_ AQDVQ 166_ KFMDA 171_ VNKKS 176_ SSQDL 181_ HKGTL 186_ SQMSG 191_ ELSKD 196_ GDLIV 201_ SMRIL 206_ GKKRT 211_ KTWHK 216_ GTLIA 221_ IQTVG 226_ PGKKY 231_ KVKFD 236_ NKGKS 241_ LLSGN 246_ HIAYD 251_ YHPPA 256_ DKLYV 261_ GSRVV 266_ AKYKD 271_ GNQVW 276_ LYAGI 281_ VAETP 286_ NVKNK 291_ LRFLI 296_ FFDDG 301_ YASYV 306_ TQSEL 311_ YPICR 316_ PLKKT 321_ WEDIE 326_ DISCR 331_ DFIEE 336_ YVTAY 341_ PNRPM 346_ VLLKS 351_ GQLIK 356_ TEWEG 361_ TWWKS 366_ RVEEV 371_ DGSLV 376_ RILFL 381_ DDKRC 386_ EWIYR 391_ GSTRL 396_ EPMFS 401_ MKTSS 406_ ASALE 411_ KKQGQ 416_ LRTRP 421_ NMGAV 426_ RSKGP 431_ VVQYT 436_ QDLTG 441_ TGTQF 446_ KPVEP 451_ PQPTA 456_ PPAPP 461_ FPPAP 466_ PLSPQ 471_ AGDSD 476_ LESQL 481_ AQSRK 486_ QVAKK 491_ STSFR 496_ PGSVG 501_ SGHSS 506_ PTSPA 511_ LSENV 516_ SGGKP 521_ GINQT 526_ YRSPL 531_ GSTAS 536_ APAPS 541_ ALPAP 546_ PAPPV 551_ FHGML 556_ ERAPA 561_ EPSYR 566_ APMEK 571_ LFYLP 576_ HVCSY 581_ TCLSR 586_ VRPMR 591_ NEQYR 596_ GKNPL 601_ LVPLL 606_ YDFRR 611_ MTARR 616_ RVNRK 621_ MGFHV 626_ IYKTP 631_ CGLCL 636_ RTMQE 641_ IERYL 646_ FETGC 651_ DFLFL 656_ EMFCL 661_ DPYVL 666_ VDRKF 671_ QPYKP 676_ FYYIL 681_ DITYG 686_ KEDVP 691_ LSCVN 696_ EIDTT 701_ PPPQV 706_ AYSKE 711_ RIPGK 716_ GVFIN 721_ TGPEF 726_ LVGCD 731_ CKDGC 736_ RDKSK 741_ CACHQ 746_ LTIQA 751_ TACTP 756_ GGQIN 761_ PNSGY 766_ QYKRL 771_ EECLP 776_ TGVYE 781_ CNKRC 786_ KCDPN 791_ MCTNR 796_ LVQHG 801_ LQVRL 806_ QLFKT 811_ QNKGW 816_ GIRCL 821_ DDIAK 826_ GSFVC 831_ IYAGK 836_ ILTDD 841_ FADKE 846_ GLEMG 851_ DEYFA 856_ NLDHI 861_ ESVEN 866_ FKEGY 871_ ESDAP 876_ CSSDS 881_ SGVDL 886_ KDQED 891_ GNSGT 896_ EDPEE 901_ SNDDS 906_ SDDNF 911_ CKDED 916_ FSTSS 921_ VWRSY 926_ ATRRQ 931_ TRGQK 936_ ENGLS 941_ ETTSK 946_ DSHPP 951_ DLGPP 956_ HIPVP 961_ PSIPV 966_ GGCNP 971_ PSSEE 976_ TPKNK 981_ VASWL 986_ SCNSV 991_ SEGGF 996_ ADSDS 1001_ HSSFK 1006_ TNEGG 1011_ EGRAG 1016_ GSRME 1021_ AEKAS 1026_ TSGLG 1031_ IKDEG 1036_ DIKQA 1041_ KKEDT 1046_ DDRNK 1051_ MSVVT 1056_ ESSRN 1061_ YGYNP 1066_ SPVKP 1071_ EGLRR 1076_ PPSKT 1081_ SMHQS 1086_ RRLMA 1091_ SAQSN 1096_ PDDVL 1101_ TLSSS 1106_ TESEG 1111_ ESGTS 1116_ RKPTA 1121_ GQTSA 1126_ TAVDS 1131_ DDIQT 1136_ ISSGS 1141_ EGDDF 1146_ EDKKN 1151_ MTGPM 1156_ KRQVA 1161_ VKSTR 1166_ GFALK 1171_ STHGI 1176_ AIKST 1181_ NMASV 1186_ DKGES 1191_ APVRK 1196_ NTRQF 1201_ YDGEE 1206_ SCYII 1211_ DAKLE 1216_ GNLGR 1221_ YLNHS 1226_ CSPNL 1231_ FVQNV 1236_ FVDTH 1241_ DLRFP 1246_ WVAFF 1251_ ASKRI 1256_ RAGTE 1261_ LTWDY 1266_ NYEVG 1271_ SVEGK 1276_ ELLCC 1281_ CGAIE 1286_CRGRL
1: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation (PubMed:12869583, PubMed:27237050, PubMed:39096901). Required for HUSH-mediated heterochromatin formation and gene silencing. Forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation (PubMed:14536086, PubMed:27732843). Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1 (PubMed:14536086). SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). In ESCs, in collaboration with TRIM28, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610)