Bromodomain-containing protein 3 (RING3-like protein)
1_MSTAT 6_ TVAPA 11_ GIPAT 16_ PGPVN 21_ PPPPE 26_ VSNPS 31_ KPGRK 36_ TNQLQ 41_ YMQNV 46_ VVKTL 51_ WKHQF 56_ AWPFY 61_ QPVDA 66_ IKLNL 71_ PDYHK 76_ IIKNP 81_ MDMGT 86_ IKKRL 91_ ENNYY 96_ WSASE 101_ CMQDF 106_ NTMFT 111_ NCYIY 116_ NKPTD 121_ DIVLM 126_ AQALE 131_ KIFLQ 136_ KVAQM 141_ PQEEV 146_ ELLPP 151_ APKGK 156_ GRKPA 161_ AGAQS 166_ AGTQQ 171_ VAAVS 176_ SVSPA 181_ TPFQS 186_ VPPTV 191_ SQTPV 196_ IAATP 201_ VPTIT 206_ ANVTS 211_ VPVPP 216_ AAAPP 221_ PPATP 226_ IVPVV 231_ PPTPP 236_ VVKKK 241_ GVKRK 246_ ADTTT 251_ PTTSA 256_ ITASR 261_ SESPP 266_ PLSDP 271_ KQAKV 276_ VARRE 281_ SGGRP 286_ IKPPK 291_ KDLED 296_ GEVPQ 301_ HAGKK 306_ GKLSE 311_ HLRYC 316_ DSILR 321_ EMLSK 326_ KHAAY 331_ AWPFY 336_ KPVDA 341_ EALEL 346_ HDYHD 351_ IIKHP 356_ MDLST 361_ VKRKM 366_ DGREY 371_ PDAQG 376_ FAADV 381_ RLMFS 386_ NCYKY 391_ NPPDH 396_ EVVAM 401_ ARKLQ 406_ DVFEM 411_ RFAKM 416_ PDEPV 421_ EAPAL 426_ PAPAA 431_ PMVSK 436_ GAESS 441_ RSSEE 446_ SSSDS 451_ GSSDS 456_ EEERA 461_ TRLAE 466_ LQEQL 471_ KAVHE 476_ QLAAL 481_ SQAPV 486_ NKPKK 491_ KKEKK 496_ EKEKK 501_ KKDKE 506_ KEKEK 511_ HKVKA 516_ EEEKK 521_ AKVAP 526_ PAKQA 531_ QQKKA 536_ PAKKA 541_ NSTTT 546_ AGRQL 551_ KKGGK 556_ QASAS 561_ YDSEE 566_ EEEGL 571_ PMSYD 576_ EKRQL 581_ SLDIN 586_ RLPGE 591_ KLGRV 596_ VHIIQ 601_ SREPS 606_ LRDSN 611_ PDEIE 616_ IDFET 621_ LKPTT 626_ LRELE 631_ RYVKS 636_ CLQKK 641_ QRKPF 646_ SASGK 651_ KQAAK 656_ SKEEL 661_ AQEKK 666_ KELEK 671_ RLQDV 676_ SGQLS 681_ SSKKP 686_ ARKEK 691_ PGSAP 696_ SGGPS 701_ RLSSS 706_ SSSES 711_ GSSSS 716_ SGSSS 721_DSSDS
1: Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity)