WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)
1_MAAGG 6_ GGSCD 11_ PLAPA 16_ GVPCA 21_ FSPHS 26_ QAYFA 31_ LASTD 36_ GHLRV 41_ WETAN 46_ NRLHQ 51_ EYVPS 56_ AHLSG 61_ TCTCL 66_ AWAPA 71_ RLQAK 76_ ESPQR 81_ KKRKS 86_ EAVGM 91_ SNQTD 96_ LLALG 101_ TAVGS 106_ ILLYS 111_ TVKGE 116_ LHSKL 121_ ISGGH 126_ DNRVN 131_ CIQWH 136_ QDSGC 141_ LYSCS 146_ DDKHI 151_ VEWNV 156_ QTCKV 161_ KCKWK 166_ GDNSS 171_ VSSLC 176_ ISPDG 181_ KMLLS 186_ AGRTI 191_ KLWVL 196_ ETKEV 201_ YRHFT 206_ GHATP 211_ VSSLM 216_ FTTIR 221_ PPNES 226_ QPFDG 231_ ITGLY 236_ FLSGA 241_ VHDRL 246_ LNVWQ 251_ VRSEN 256_ KEKSA 261_ VMSFT 266_ VTDEP 271_ VYIDL 276_ TLSEN 281_ KEEPV 286_ KLAVV 291_ CRDGQ 296_ VHLFE 301_ HILNG 306_ YCKKP 311_ LTSNC 316_ TIQIA 321_ TPGKG 326_ KKSTP 331_ KPIPI 336_ LAAGF 341_ CSDKM 346_ SLLLV 351_ YGSWF 356_ QPTIE 361_ RVALN 366_ SREPH 371_ MCLVR 376_ DISNC 381_ WAPKV 386_ ETAIT 391_ KVRTP 396_ VMNSE 401_ AKVLV 406_ PGIPG 411_ HHAAI 416_ KPAPP 421_ QTEQV 426_ ESKRK 431_ SGGNE 436_ VSIEE 441_ RLGAM 446_ DIDTH 451_ KKGKE 456_ DLQTN 461_ SFPVL 466_ LTQGL 471_ ESNDF 476_ EMLNK 481_ VLQTR 486_ NVNLI 491_ KKTVL 496_ RMPLH 501_ TIIPL 506_ LQELT 511_ KRLQG 516_ HPNSA 521_ VLMVQ 526_ WLKCV 531_ LTVHA 536_ SYLST 541_ LPDLV 546_ PQLGT 551_ LYQLM 556_ ESRVK 561_ TFQKL 566_ SHLHG 571_ KLILL 576_ ITQVT 581_ ASEKT 586_ KGATS 591_ PGQKA 596_ KLVYE 601_ EESSE 606_ EESDD 611_ EIADK 616_ DSEDN 621_ WDEDE 626_ EESES 631_ EKDED 636_ VEEED 641_ EDAEG 646_ KDEEN 651_ GEDRD 656_ TASEK 661_ ELNGD 666_ SDLDP 671_ENESE
1: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity)