Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]
1_MNPDL 6_ RRERD 11_ SASFN 16_ PELLT 21_ HILDG 26_ SPEKT 31_ RRRRE 36_ IENMI 41_ LNDPD 46_ FQHED 51_ LNFLT 56_ RSQRY 61_ EVAVR 66_ KSAIM 71_ VKKMR 76_ EFGIA 81_ DPDEI 86_ MWFKK 91_ LHLVN 96_ FVEPV 101_ GLNYS 106_ MFIPT 111_ LLNQG 116_ TTAQK 121_ EKWLL 126_ SSKGL 131_ QIIGT 136_ YAQTE 141_ MGHGT 146_ HLRGL 151_ ETTAT 156_ YDPET 161_ QEFIL 166_ NSPTV 171_ TSIKW 176_ WPGGL 181_ GKTSN 186_ HAIVL 191_ AQLIT 196_ KGKCY 201_ GLHAF 206_ IVPIR 211_ EIGTH 216_ KPLPG 221_ ITVGD 226_ IGPKF 231_ GYDEI 236_ DNGYL 241_ KMDNH 246_ RIPRE 251_ NMLMK 256_ YAQVK 261_ PDGTY 266_ VKPLS 271_ NKLTY 276_ GTMVF 281_ VRSFL 286_ VGEAA 291_ RALSK 296_ ACTIA 301_ IRYSA 306_ VRHQS 311_ EIKPG 316_ EPEPQ 321_ ILDFQ 326_ TQQYK 331_ LFPLL 336_ ATAYA 341_ FQFVG 346_ AYMKE 351_ TYHRI 356_ NEGIG 361_ QGDLS 366_ ELPEL 371_ HALTA 376_ GLKAF 381_ TSWTA 386_ NTGIE 391_ ACRMA 396_ CGGHG 401_ YSHCS 406_ GLPNI 411_ YVNFT 416_ PSCTF 421_ EGENT 426_ VMMLQ 431_ TARFL 436_ MKSYD 441_ QVHSG 446_ KLVCG 451_ MVSYL 456_ NDLPS 461_ QRIQP 466_ QQVAV 471_ WPTMV 476_ DINSP 481_ ESLTE 486_ AYKLR 491_ AARLV 496_ EIAAK 501_ NLQKE 506_ VIHRK 511_ SKEVA 516_ WNLTS 521_ VDLVR 526_ ASEAH 531_ CHYVV 536_ VKLFS 541_ EKLLK 546_ IQDKA 551_ IQAVL 556_ RSLCL 561_ LYSLY 566_ GISQN 571_ AGDFL 576_ QGSIM 581_ TEPQI 586_ TQVNQ 591_ RVKEL 596_ LTLIR 601_ SDAVA 606_ LVDAF 611_ DFQDV 616_ TLGSV 621_ LGRYD 626_ GNVYE 631_ NLFEW 636_ AKNSP 641_ LNKAE 646_ VHESY 651_KHLKS
1: Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids (PubMed:15060085, PubMed:17458872, PubMed:17603022, PubMed:32169171, PubMed:33234382, PubMed:7876265). Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)) (PubMed:17458872, PubMed:17603022, PubMed:7876265)
2: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro
3: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs