Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]
1_MGTVL 6_ SLSPS 11_ YRKAT 16_ LFEDG 21_ AATVG 26_ HYTAV 31_ QNSKN 36_ AKDKN 41_ LKRHS 46_ IISVL 51_ PWKRI 56_ VAVSA 61_ KKKNS 66_ KKVQP 71_ NSSYQ 76_ NNITH 81_ LNNEN 86_ LKKSL 91_ SCANL 96_ STFAQ 101_ PPPAQ 106_ PPAPP 111_ ASQLS 116_ GSQTG 121_ GSSSV 126_ KKAPH 131_ PAVTS 136_ AGTPK 141_ RVIVQ 146_ ASTSE 151_ LLRCL 156_ GEFLC 161_ RRCYR 166_ LKHLS 171_ PTDPV 176_ LWLRS 181_ VDRSL 186_ LLQGW 191_ QDQGF 196_ ITPAN 201_ VVFLY 206_ MLCRD 211_ VISSE 216_ VGSDH 221_ ELQAV 226_ LLTCL 231_ YLSYS 236_ YMGNE 241_ ISYPL 246_ KPFLV 251_ ESCKE 256_ AFWDR 261_ CLSVI 266_ NLMSS 271_ KMLQI 276_ NADPH 281_ YFTQV 286_ FSDLK 291_ NESGQ 296_ EDKKR 301_LLLGL
1: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution