Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox)
1_MAVAQ 6_ QLRAE 11_ SDFEQ 16_ LPDDV 21_ AISAN 26_ IADIE 31_ EKRGF 36_ TSHFV 41_ FVIEV 46_ KTKGG 51_ SKYLI 56_ YRRYR 61_ QFHAL 66_ QSKLE 71_ ERFGP 76_ DSKSS 81_ ALACT 86_ LPTLP 91_ AKVYV 96_ GVKQE 101_ IAEMR 106_ IPALN 111_ AYMKS 116_ LLSLP 121_ VWVLM 126_ DEDVR 131_ IFFYQ 136_ SPYDS 141_ EQVPQ 146_ ALRRL 151_ RPRTR 156_ KVKSV 161_ SPQGN 166_ SVDRM 171_ AAPRA 176_ EALFD 181_ FTGNS 186_ KLELN 191_ FKAGD 196_ VIFLL 201_ SRINK 206_ DWLEG 211_ TVRGA 216_ TGIFP 221_ LSFVK 226_ ILKDF 231_ PEEDD 236_ PTNWL 241_ RCYYY 246_ EDTIS 251_ TIKDI 256_ AVEED 261_ LSSTP 266_ LLKDL 271_ LELTR 276_ REFQR 281_ EDIAL 286_ NYRDA 291_ EGDLV 296_ RLLSD 301_ EDVAL 306_ MVRQA 311_ RGLPS 316_ QKRLF 321_ PWKLH 326_ ITQKD 331_NYRVY
1: Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (Probable). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (By similarity). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity)