Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
1_MALLV 6_ LGLVS 11_ CTFFL 16_ AVNGL 21_ YSSSD 26_ DVIEL 31_ TPSNF 36_ NREVI 41_ QSDSL 46_ WLVEF 51_ YAPWC 56_ GHCQR 61_ LTPEW 66_ KKAAT 71_ ALKDV 76_ VKVGA 81_ VDADK 86_ HHSLG 91_ GQYGV 96_ QGFPT 101_ IKIFG 106_ SNKNR 111_ PEDYQ 116_ GGRTG 121_ EAIVD 126_ AALSA 131_ LRQLV 136_ KDRLG 141_ GRSGG 146_ YSSGK 151_ QGRSD 156_ SSSKK 161_ DVIEL 166_ TDDSF 171_ DKNVL 176_ DSEDV 181_ WMVEF 186_ YAPWC 191_ GHCKN 196_ LEPEW 201_ AAAAS 206_ EVKEQ 211_ TKGKV 216_ KLAAV 221_ DATVN 226_ QVLAS 231_ RYGIR 236_ GFPTI 241_ KIFQK 246_ GESPV 251_ DYDGG 256_ RTRSD 261_ IVSRA 266_ LDLFS 271_ DNAPP 276_ PELLE 281_ IINED 286_ IAKRT 291_ CEEHQ 296_ LCVVA 301_ VLPHI 306_ LDTGA 311_ AGRNS 316_ YLEVL 321_ LKLAD 326_ KYKKK 331_ MWGWL 336_ WTEAG 341_ AQSEL 346_ ETALG 351_ IGGFG 356_ YPAMA 361_ AINAR 366_ KMKFA 371_ LLKGS 376_ FSEQG 381_ INEFL 386_ RELSF 391_ GRGST 396_ APVGG 401_ GAFPT 406_ IVERE 411_ PWDGR 416_ DGELP 421_ VEDDI 426_ DLSDV 431_ELDDL
1: May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936)