Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)
1_MSGEE 6_ NPASK 11_ PTPVQ 16_ DVQGD 21_ GRWMS 26_ LHHRF 31_ VADSK 36_ DKEPE 41_ VVFIG 46_ DSLVQ 51_ LMHQC 56_ EIWRE 61_ LFSPL 66_ HALNF 71_ GIGGD 76_ GTQHV 81_ LWRLE 86_ NGELE 91_ HIRPK 96_ IVVVW 101_ VGTNN 106_ HGHTA 111_ EQVTG 116_ GIKAI 121_ VQLVN 126_ ERQPQ 131_ ARVVV 136_ LGLLP 141_ RGQHP 146_ NPLRE 151_ KNRQV 156_ NELVR 161_ AALAG 166_ HPRAH 171_ FLDAD 176_ PGFVH 181_ SDGTI 186_ SHHDM 191_ YDYLH 196_ LSRLG 201_ YTPVC 206_ RALHS 211_ LLLRL 216_ LAQDQ 221_ GQGAP 226_LLEPA
1: Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain