[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
1_MRLAR 6_ LLRGA 11_ ALAGP 16_ GPGLR 21_ AAGFS 26_ RSFSS 31_ DSGSS 36_ PASER 41_ GVPGQ 46_ VDFYA 51_ RFSPS 56_ PLSMK 61_ QFLDF 66_ GSVNA 71_ CEKTS 76_ FMFLR 81_ QELPV 86_ RLANI 91_ MKEIS 96_ LLPDN 101_ LLRTP 106_ SVQLV 111_ QSWYI 116_ QSLQE 121_ LLDFK 126_ DKSAE 131_ DAKAI 136_ YDFTD 141_ TVIRI 146_ RNRHN 151_ DVIPT 156_ MAQGV 161_ IEYKE 166_ SFGVD 171_ PVTSQ 176_ NVQYF 181_ LDRFY 186_ MSRIS 191_ IRMLL 196_ NQHSL 201_ LFGGK 206_ GKGSP 211_ SHRKH 216_ IGSIN 221_ PNCNV 226_ LEVIK 231_ DGYEN 236_ ARRLC 241_ DLYYI 246_ NSPEL 251_ ELEEL 256_ NAKSP 261_ GQPIQ 266_ VVYVP 271_ SHLYH 276_ MVFEL 281_ FKNAM 286_ RATME 291_ HHANR 296_ GVYPP 301_ IQVHV 306_ TLGNE 311_ DLTVK 316_ MSDRG 321_ GGVPL 326_ RKIDR 331_ LFNYM 336_ YSTAP 341_ RPRVE 346_ TSRAV 351_ PLAGF 356_ GYGLP 361_ ISRLY 366_ AQYFQ 371_ GDLKL 376_ YSLEG 381_ YGTDA 386_ VIYIK 391_ ALSTD 396_ SIERL 401_ PVYNK 406_ AAWKH 411_ YNTNH 416_ EADDW 421_ CVPSR 426_ EPKDM 431_TTFRS
1: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675)