[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)
1_MRWVW 6_ ALLKN 11_ ASLAG 16_ APKYI 21_ EHFSK 26_ FSPSP 31_ LSMKQ 36_ FLDFG 41_ SSNAC 46_ EKTSF 51_ TFLRQ 56_ ELPVR 61_ LANIM 66_ KEINL 71_ LPDRV 76_ LSTPS 81_ VQLVQ 86_ SWYVQ 91_ SLLDI 96_ MEFLD 101_ KDPED 106_ HRTLS 111_ QFTDA 116_ LVTIR 121_ NRHND 126_ VVPTM 131_ AQGVL 136_ EYKDT 141_ YGDDP 146_ VSNQN 151_ IQYFL 156_ DRFYL 161_ SRISI 166_ RMLIN 171_ QHTLI 176_ FDGST 181_ NPAHP 186_ KHIGS 191_ IDPNC 196_ NVSEV 201_ VKDAY 206_ DMAKL 211_ LCDKY 216_ YMASP 221_ DLEIQ 226_ EINAA 231_ NSKQP 236_ IHMVY 241_ VPSHL 246_ YHMLF 251_ ELFKN 256_ AMRAT 261_ VESHE 266_ SSLIL 271_ PPIKV 276_ MVALG 281_ EEDLS 286_ IKMSD 291_ RGGGV 296_ PLRKI 301_ ERLFS 306_ YMYST 311_ APTPQ 316_ PGTGG 321_ TPLAG 326_ FGYGL 331_ PISRL 336_ YAKYF 341_ QGDLQ 346_ LFSME 351_ GFGTD 356_ AVIYL 361_ KALST 366_ DSVER 371_ LPVYN 376_ KSAWR 381_ HYQTI 386_ QEAGD 391_ WCVPS 396_ TEPKN 401_TSTYR
1: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis