[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)
1_MRLFR 6_ WLLKQ 11_ PVPKQ 16_ IERYS 21_ RFSPS 26_ PLSIK 31_ QFLDF 36_ GRDNA 41_ CEKTS 46_ YMFLR 51_ KELPV 56_ RLANT 61_ MREVN 66_ LLPDN 71_ LLNRP 76_ SVGLV 81_ QSWYM 86_ QSFLE 91_ LLEYE 96_ NKSPE 101_ DPQVL 106_ DNFLQ 111_ VLIKV 116_ RNRHN 121_ DVVPT 126_ MAQGV 131_ IEYKE 136_ KFGFD 141_ PFIST 146_ NIQYF 151_ LDRFY 156_ TNRIS 161_ FRMLI 166_ NQHTL 171_ LFGGD 176_ TNPVH 181_ PKHIG 186_ SIDPT 191_ CNVAD 196_ VVKDA 201_ YETAK 206_ MLCEQ 211_ YYLVA 216_ PELEV 221_ EEFNA 226_ KAPDK 231_ PIQVV 236_ YVPSH 241_ LFHML 246_ FELFK 251_ NSMRA 256_ TVELY 261_ EDRKE 266_ GYPAV 271_ KTLVT 276_ LGKED 281_ LSIKI 286_ SDLGG 291_ GVPLR 296_ KIDRL 301_ FNYMY 306_ STAPR 311_ PSLEP 316_ TRAAP 321_ LAGFG 326_ YGLPI 331_ SRLYA 336_ RYFQG 341_ DLKLY 346_ SMEGV 351_ GTDAV 356_ IYLKA 361_ LSSES 366_ FERLP 371_ VFNKS 376_ AWRHY 381_ KTTPE 386_ ADDWS 391_ NPSSE 396_ PRDAS 401_KYKAK
1: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species