Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)
1_MAEYG 6_ TLLQD 11_ LTNNI 16_ TLEDL 21_ EQLKS 26_ ACKED 31_ IPSEK 36_ SEEIT 41_ TGSAW 46_ FSFLE 51_ SHNKL 56_ DKDNL 61_ SYIEH 66_ IFEIS 71_ RRPDL 76_ LTMVV 81_ DYRTR 86_ VLKIS 91_ EEDEL 96_ DTKLT 101_ RIPSA 106_ KKYKD 111_ IIRQP 116_ SEEEI 121_IKLAP
1: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface