3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)
1_MTTNA 6_ GPLHP 11_ YWPQH 16_ LRLDN 21_ FVPND 26_ RPTWH 31_ ILAGL 36_ FSVTG 41_ VLVVT 46_ TWLLS 51_ GRAAV 56_ VPLGT 61_ WRRLS 66_ LCWFA 71_ VCGFI 76_ HLVIE 81_ GWFVL 86_ YYEDL 91_ LGDQA 96_ FLSQL 101_ WKEYA 106_ KGDSR 111_ YILGD 116_ NFTVC 121_ METIT 126_ ACLWG 131_ PLSLW 136_ VVIAF 141_ LRQHP 146_ LRFIL 151_ QLVVS 156_ VGQIY 161_ GDVLY 166_ FLTEH 171_ RDGFQ 176_ HGELG 181_ HPLYF 186_ WFYFV 191_ FMNAL 196_ WLVLP 201_ GVLVL 206_ DAVKH 211_ LTHAQ 216_ STLDA 221_KATKA
1: Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers a catalytic step in the postlanosterol biosynthesis of cholesterol
2: Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between EBP and 7-dehydrocholesterol reductase/DHCR7 (PubMed:15175332, PubMed:20615952). This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT) (PubMed:20615952). The precise role of each component of this complex has not been described yet (PubMed:20615952)