Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE)
1_MAEPD 6_ LECEQ 11_ IRLKC 16_ IRKEG 21_ FFTVP 26_ PEHRL 31_ GRCRS 36_ VKEFE 41_ KLNRI 46_ GEGTY 51_ GIVYR 56_ ARDTQ 61_ TDEIV 66_ ALKKV 71_ RMDKE 76_ KDGIP 81_ ISSLR 86_ EITLL 91_ LRLRH 96_ PNIVE 101_ LKEVV 106_ VGNHL 111_ ESIFL 116_ VMGYC 121_ EQDLA 126_ SLLEN 131_ MPTPF 136_ SEAQV 141_ KCIVL 146_ QVLRG 151_ LQYLH 156_ RNFII 161_ HRDLK 166_ VSNLL 171_ MTDKG 176_ CVKTA 181_ DFGLA 186_ RAYGV 191_ PVKPM 196_ TPKVV 201_ TLWYR 206_ APELL 211_ LGTTT 216_ QTTSI 221_ DMWAV 226_ GCILA 231_ ELLAH 236_ RPLLP 241_ GTSEI 246_ HQIDL 251_ IVQLL 256_ GTPSE 261_ NIWPG 266_ FSKLP 271_ LVGQY 276_ SLRKQ 281_ PYNNL 286_ KHKFP 291_ WLSEA 296_ GLRLL 301_ HFLFM 306_ YDPKK 311_ RATAG 316_ DCLES 321_ SYFKE 326_ KPLPC 331_ EPELM 336_ PTFPH 341_ HRNKR 346_ AAPAT 351_SEGQS
1: Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747)