Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
1_MSAPP 6_ VLRPP 11_ SPLLP 16_ VAAAA 21_ AAAAA 26_ ALVPG 31_ SGPGP 36_ APFLA 41_ PVAAP 46_ VGGIS 51_ FHLQI 56_ GLSRE 61_ PVLLL 66_ QDSSG 71_ DYSLA 76_ HVREM 81_ ACSIV 86_ DQKFP 91_ ECGFY 96_ GMYDK 101_ ILLFR 106_ HDPTS 111_ ENILQ 116_ LVKAA 121_ SDIQE 126_ GDLIE 131_ VVLSA 136_ SATFE 141_ DFQIR 146_ PHALF 151_ VHSYR 156_ APAFC 161_ DHCGE 166_ MLWGL 171_ VRQGL 176_ KCEGC 181_ GLNYH 186_ KRCAF 191_ KIPNN 196_ CSGVR 201_ RRRLS 206_ NVSLT 211_ GVSTI 216_ RTSSA 221_ ELSTS 226_ APDEP 231_ LLQKS 236_ PSESF 241_ IGREK 246_ RSNSQ 251_ SYIGR 256_ PIHLD 261_ KILMS 266_ KVKVP 271_ HTFVI 276_ HSYTR 281_ PTVCQ 286_ YCKKL 291_ LKGLF 296_ RQGLQ 301_ CKDCR 306_ FNCHK 311_ RCAPK 316_ VPNNC 321_ LGEVT 326_ INGDL 331_ LSPGA 336_ ESDVV 341_ MEEGS 346_ DDNDS 351_ ERNSG 356_ LMDDM 361_ EEAMV 366_ QDAEM 371_ AMAEC 376_ QNDSG 381_ EMQDP 386_ DPDHE 391_ DANRT 396_ ISPST 401_ SNNIP 406_ LMRVV 411_ QSVKH 416_ TKRKS 421_ STVMK 426_ EGWMV 431_ HYTSK 436_ DTLRK 441_ RHYWR 446_ LDSKC 451_ ITLFQ 456_ NDTGS 461_ RYYKE 466_ IPLSE 471_ ILSLE 476_ PVKTS 481_ ALIPN 486_ GANPH 491_ CFEIT 496_ TANVV 501_ YYVGE 506_ NVVNP 511_ SSPSP 516_ NNSVL 521_ TSGVG 526_ ADVAR 531_ MWEIA 536_ IQHAL 541_ MPVIP 546_ KGSSV 551_ GTGTN 556_ LHRDI 561_ SVSIS 566_ VSNCQ 571_ IQENV 576_ DISTV 581_ YQIFP 586_ DEVLG 591_ SGQFG 596_ IVYGG 601_ KHRKT 606_ GRDVA 611_ IKIID 616_ KLRFP 621_ TKQES 626_ QLRNE 631_ VAILQ 636_ NLHHP 641_ GVVNL 646_ ECMFE 651_ TPERV 656_ FVVME 661_ KLHGD 666_ MLEMI 671_ LSSEK 676_ GRLPE 681_ HITKF 686_ LITQI 691_ LVALR 696_ HLHFK 701_ NIVHC 706_ DLKPE 711_ NVLLA 716_ SADPF 721_ PQVKL 726_ CDFGF 731_ ARIIG 736_ EKSFR 741_ RSVVG 746_ TPAYL 751_ APEVL 756_ RNKGY 761_ NRSLD 766_ MWSVG 771_ VIIYV 776_ SLSGT 781_ FPFNE 786_ DEDIH 791_ DQIQN 796_ AAFMY 801_ PPNPW 806_ KEISH 811_ EAIDL 816_ INNLL 821_ QVKMR 826_ KRYSV 831_ DKTLS 836_ HPWLQ 841_ DYQTW 846_ LDLRE 851_ LECKI 856_ GERYI 861_ THESD 866_ DLRWE 871_ KYAGE 876_ QGLQY 881_ PTHLI 886_ NPSAS 891_ HSDTP 896_ ETEET 901_ EMKAL 906_GERVS
1: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity)