1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
1_MAKPY 6_ EFNWQ 11_ KEVPS 16_ FLQEG 21_ AVFDR 26_ YEEES 31_ FVFEP 36_ NCLFK 41_ VDEFG 46_ FFLTW 51_ RSEGK 56_ EGQVL 61_ ECSLI 66_ NSIRS 71_ GAIPK 76_ DPKIL 81_ AALEA 86_ VGKSE 91_ NDLEG 96_ RIVCV 101_ CSGTD 106_ LVNIS 111_ FTYMV 116_ AENPE 121_ VTKQW 126_ VEGLR 131_ SIIHN 136_ FRANN 141_ VSPMT 146_ CLKKH 151_ WMKLA 156_ FMTNT 161_ NGKIP 166_ VRSIT 171_ RTFAS 176_ GKTEK 181_ VIFQA 186_ LKELG 191_ LPSGK 196_ NDEIE 201_ PTAFS 206_ YEKFY 211_ ELTQK 216_ ICPRT 221_ DIEDL 226_ FKKIN 231_ GDKTD 236_ YLTVD 241_ QLVSF 246_ LNEHQ 251_ RDPRL 256_ NEILF 261_ PFYDA 266_ KRAMQ 271_ IIEMY 276_ EPDED 281_ LKKKG 286_ LISSD 291_ GFCRY 296_ LMSDE 301_ NAPVF 306_ LDRLE 311_ LYQEM 316_ DHPLA 321_ HYFIS 326_ SSHNT 331_ YLTGR 336_ QFGGK 341_ SSVEM 346_ YRQVL 351_ LAGCR 356_ CVELD 361_ CWDGK 366_ GEDQE 371_ PIITH 376_ GKAMC 381_ TDILF 386_ KDVIQ 391_ AIKET 396_ AFVTS 401_ EYPVI 406_ LSFEN 411_ HCSKY 416_ QQYKM 421_ SKYCE 426_ DLFGD 431_ LLLKQ 436_ ALESH 441_ PLEPG 446_ RALPS 451_ PNDLK 456_ RKILI 461_ KNKRL 466_ KPEVE 471_ KKQLE 476_ ALRSM 481_ MEAGE 486_ SASPA 491_ NILED 496_ DNEEE 501_ IESAD 506_ QEEEA 511_ HPEFK 516_ FGNEL 521_ SADDL 526_ GHKEA 531_ VANSV 536_ KKGLV 541_ TVEDE 546_ QAWMA 551_ SYKYV 556_ GATTN 561_ IHPYL 566_ STMIN 571_ YAQPV 576_ KFQGF 581_ HVAEE 586_ RNIHY 591_ NMSSF 596_ NESVG 601_ LGYLK 606_ THAIE 611_ FVNYN 616_ KRQMS 621_ RIYPK 626_ GGRVD 631_ SSNYM 636_ PQIFW 641_ NAGCQ 646_ MVSLN 651_ YQTPD 656_ LAMQL 661_ NQGKF 666_ EYNGS 671_ CGYLL 676_ KPDFM 681_ RRPDR 686_ TFDPF 691_ SETPV 696_ DGVIA 701_ ATCSV 706_ QVISG 711_ QFLSD 716_ KKIGT 721_ YVEVD 726_ MYGLP 731_ TDTIR 736_ KEFRT 741_ RMVMN 746_ NGLNP 751_ VYNEE 756_ SFVFR 761_ KVILP 766_ DLAVL 771_ RIAVY 776_ DDNNK 781_ LIGQR 786_ ILPLD 791_ GLQAG 796_ YRHIS 801_ LRNEG 806_ NKPLS 811_ LPTIF 816_ CNIVL 821_ KTYVP 826_ DGFGD 831_ IVDAL 836_ SDPKK 841_ FLSIT 846_ EKRAD 851_ QMRAM 856_ GIETS 861_ DIADV 866_ PSDTS 871_ KNDKK 876_ GKANT 881_ AKANV 886_ TPQSS 891_ SELRP 896_ TTTAA 901_ LASGV 906_ EAKKG 911_ IELIP 916_ QVRIE 921_ DLKQM 926_ KAYLK 931_ HLKKQ 936_ QKELN 941_ SLKKK 946_ HAKEH 951_ STMQK 956_ LHCTQ 961_ VDKIV 966_ AQYDK 971_ EKSTH 976_ EKILE 981_ KAMKK 986_ KGGSN 991_ CLEMK 996_ KETEI 1001_ KIQTL 1006_ TSDHK 1011_ SKVKE 1016_ IVAQH 1021_ TKEWS 1026_ EMINT 1031_ HSAEE 1036_ QEIRD 1041_ LHLSQ 1046_ QCELL 1051_ KKLLI 1056_ NAHEQ 1061_ QTQQL 1066_ KLSHD 1071_ RESKE 1076_ MRAHQ 1081_ AKISM 1086_ ENSKA 1091_ ISQDK 1096_ SIKNK 1101_ AERER 1106_ RVREL 1111_ NSSNT 1116_ KKFLE 1121_ ERKRL 1126_ AMKQS 1131_ KEMDQ 1136_ LKKVQ 1141_ LEHLE 1146_ FLEKQ 1151_ NEQAK 1156_ EMQQM 1161_ VKLEA 1166_EMDRR
1: Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development (PubMed:35284927)