Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)
1_MGKLV 6_ ALVLL 11_ GVGLS 16_ LVGEM 21_ FLAFR 26_ ERVNA 31_ SREVE 36_ PVEPE 41_ NCHLI 46_ EELES 51_ GSEDI 56_ DILPS 61_ GLAFI 66_ SSGLK 71_ YPGMP 76_ NFAPD 81_ EPGKI 86_ FLMDL 91_ NEQNP 96_ RAQAL 101_ EISGG 106_ FDKEL 111_ FNPHG 116_ ISIFI 121_ DKDNT 126_ VYLYV 131_ VNHPH 136_ MKSTV 141_ EIFKF 146_ EEQQR 151_ SLVYL 156_ KTIKH 161_ ELLKS 166_ VNDIV 171_ VLGPE 176_ QFYAT 181_ RDHYF 186_ TNSLL 191_ SFFEM 196_ ILDLR 201_ WTYVL 206_ FYSPR 211_ EVKVV 216_ AKGFC 221_ SANGI 226_ TVSAD 231_ QKYVY 236_ VADVA 241_ AKNIH 246_ IMEKH 251_ DNWDL 256_ TQLKV 261_ IQLGT 266_ LVDNL 271_ TVDPA 276_ TGDIL 281_ AGCHP 286_ NPMKL 291_ LNYNP 296_ EDPPG 301_ SEVLR 306_ IQNVL 311_ SEKPR 316_ VSTVY 321_ ANNGS 326_ VLQGT 331_ SVASV 336_ YHGKI 341_ LIGTV 346_FHKTL
1: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents