Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23)
1_MQPAS 6_ AKWYD 11_ RRDYV 16_ FIEFC 21_ VEDSK 26_ DVNVN 31_ FEKSK 36_ LTFSC 41_ LGGSD 46_ NFKHL 51_ NEIDL 56_ FHCID 61_ PNDSK 66_ HKRTD 71_ RSILC 76_ CLRKG 81_ ESGQS 86_ WPRLT 91_ KERAK 96_ LNWLS 101_ VDFNN 106_ WKDWE 111_ DDSDE 116_ DMSNF 121_ DRFSE 126_ MMNNM 131_ GGDED 136_ VDLPE 141_ VDGAD 146_ DDSQD 151_SDDEK
1: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448)