Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)
1_MAMTG 6_ STPCS 11_ SMSNH 16_ TKERV 21_ TMTKV 26_ TLENF 31_ YSNLI 36_ AQHEE 41_ REMRQ 46_ KKLEK 51_ VMEEE 56_ GLKDE 61_ EKRLR 66_ RSAHA 71_ RKETE 76_ FLRLK 81_ RTRLG 86_ LEDFE 91_ SLKVI 96_ GRGAF 101_ GEVRL 106_ VQKKD 111_ TGHVY 116_ AMKIL 121_ RKADM 126_ LEKEQ 131_ VGHIR 136_ AERDI 141_ LVEAD 146_ SLWVV 151_ KMFYS 156_ FQDKL 161_ NLYLI 166_ MEFLP 171_ GGDMM 176_ TLLMK 181_ KDTLT 186_ EEETQ 191_ FYIAE 196_ TVLAI 201_ DSIHQ 206_ LGFIH 211_ RDIKP 216_ DNLLL 221_ DSKGH 226_ VKLSD 231_ FGLCT 236_ GLKKA 241_ HRTEF 246_ YRNLN 251_ HSLPS 256_ DFTFQ 261_ NMNSK 266_ RKAET 271_ WKRNR 276_ RQLAF 281_ STVGT 286_ PDYIA 291_ PEVFM 296_ QTGYN 301_ KLCDW 306_ WSLGV 311_ IMYEM 316_ LIGYP 321_ PFCSE 326_ TPQET 331_ YKKVM 336_ NWKET 341_ LTFPP 346_ EVPIS 351_ EKAKD 356_ LILRF 361_ CCEWE 366_ HRIGA 371_ PGVEE 376_ IKSNS 381_ FFEGV 386_ DWEHI 391_ RERPA 396_ AISIE 401_ IKSID 406_ DTSNF 411_ DEFPE 416_ SDILK 421_ PTVAT 426_ SNHPE 431_ TDYKN 436_ KDWVF 441_ INYTY 446_ KRFEG 451_ LTARG 456_AIPSY
1: Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488)