Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)
1_MARMG 6_ LAGAA 11_ GRWWG 16_ LALGL 21_ TAFFL 26_ PGVHS 31_ QVVQV 36_ NDSMY 41_ GFIGT 46_ DVVLH 51_ CSFAN 56_ PLPSV 61_ KITQV 66_ TWQKS 71_ TNGSK 76_ QNVAI 81_ YNPSM 86_ GVSVL 91_ APYRE 96_ RVEFL 101_ RPSFT 106_ DGTIR 111_ LSRLE 116_ LEDEG 121_ VYICE 126_ FATFP 131_ TGNRE 136_ SQLNL 141_ TVMAK 146_ PTNWI 151_ EGTQA 156_ VLRAK 161_ KGQDD 166_ KVLVA 171_ TCTSA 176_ NGKPP 181_ SVVSW 186_ ETRLK 191_ GEAEY 196_ QEIRN 201_ PNGTV 206_ TVISR 211_ YRLVP 216_ SREAH 221_ QQSLA 226_ CIVNY 231_ HMDRF 236_ KESLT 241_ LNVQY 246_ EPEVT 251_ IEGFD 256_ GNWYL 261_ QRMDV 266_ KLTCK 271_ ADANP 276_ PATEY 281_ HWTTL 286_ NGSLP 291_ KGVEA 296_ QNRTL 301_ FFKGP 306_ INYSL 311_ AGTYI 316_ CEATN 321_ PIGTR 326_ SGQVE 331_ VNITE 336_ FPYTP 341_ SPPEH 346_ GRRAG 351_ PVPTA 356_ IIGGV 361_ AGSIL 366_ LVLIV 371_ VGGIV 376_ VALRR 381_ RRHTF 386_ KGDYS 391_ TKKHV 396_ YGNGY 401_ SKAGI 406_ PQHHP 411_ PMAQN 416_ LQYPD 421_ DSDDE 426_ KKAGP 431_ LGGSS 436_ YEEEE 441_ EEEEG 446_ GGGGE 451_ RKVGG 456_ PHPKY 461_ DEDAK 466_ RPYFT 471_ VDEAE 476_ ARQDG 481_ YGDRT 486_ LGYQY 491_ DPEQL 496_ DLAEN 501_ MVSQN 506_ DGSFI 511_SKKEW
1: Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:21325282). Acts by forming homophilic or heterophilic trans-dimers (PubMed:21325282). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (By similarity). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Involved in synaptogegesis (By similarity). Has some neurite outgrowth-promoting activity (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Required for enamel mineralization (By similarity)
2: (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV (PubMed:21980294, PubMed:25231300, PubMed:28381567, PubMed:28542478, PubMed:34587223, PubMed:38857290, PubMed:39048823, PubMed:39048830, PubMed:7721102, PubMed:9616127, PubMed:9657005). Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells (PubMed:34587223)