Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')
1_MAEGE 6_ RQPPP 11_ DSSEE 16_ APPAT 21_ QNFII 26_ PKKEI 31_ HTVPD 36_ MGKWK 41_ RSQAY 46_ ADYIG 51_ FILTL 56_ NEGVK 61_ GKKLT 66_ FEYRV 71_ SEMWN 76_ EVHEE 81_ KEQAA 86_ KQSVS 91_ CDECI 96_ PLPRA 101_ GHCAP 106_ SEAIE 111_ KLVAL 116_ LNTLD 121_ RWIDE 126_ TPPVD 131_ QPSRF 136_ GNKAY 141_ RTWYA 146_ KLDEE 151_ AENLV 156_ ATVVP 161_ THLAA 166_ AVPEV 171_ AVYLK 176_ ESVGN 181_ STRID 186_ YGTGH 191_ EAAFA 196_ AFLCC 201_ LCKIG 206_ VLRVD 211_ DQIAI 216_ VFKVF 221_ NRYLE 226_ VMRKL 231_ QKTYR 236_ MEPAG 241_ SQGVW 246_ GLDDF 251_ QFLPF 256_ IWGSS 261_ QLIDH 266_ PYLEP 271_ RHFVD 276_ EKAVN 281_ ENHKD 286_ YMFLE 291_ CILFI 296_ TEMKT 301_ GPFAE 306_ HSNQL 311_ WNISA 316_ VPSWS 321_ KVNQG 326_ LIRMY 331_ KAECL 336_ EKFPV 341_ IQHFK 346_ FGSLL 351_PIHPV
1: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:16916641, PubMed:36073231). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (PubMed:16916641). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (PubMed:16916641). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (PubMed:16916641). Is involved in apoptosis; the function appears to be independent from PP2A (PubMed:17333320)