Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C)
1_MARDY 6_ DHLFK 11_ LLIIG 16_ DSGVG 21_ KSSLL 26_ LRFAD 31_ NTFSG 36_ SYITT 41_ IGVDF 46_ KIRTV 51_ EINGE 56_ KVKLQ 61_ IWDTA 66_ GQERF 71_ RTITS 76_ TYYRG 81_ THGVI 86_ VVYDV 91_ TSAES 96_ FVNVK 101_ RWLHE 106_ INQNC 111_ DDVCR 116_ ILVGN 121_ KNDDP 126_ ERKVV 131_ ETEDA 136_ YKFAG 141_ QMGIQ 146_ LFETS 151_ AKENV 156_ NVEEM 161_ FNCIT 166_ ELVLR 171_ AKKDN 176_ LAKQQ 181_ QQQQN 186_ DVVKL 191_ TKNSK 196_RKKRC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:30905672). RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane (PubMed:21951725). During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (PubMed:16950109). May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity)