Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)
1_MNLEG 6_ GGRGG 11_ EFGMS 16_ AVSCG 21_ NGKLR 26_ QWLID 31_ QIDSG 36_ KYPGL 41_ VWENE 46_ EKSIF 51_ RIPWK 56_ HAGKQ 61_ DYNRE 66_ EDAAL 71_ FKAWA 76_ LFKGK 81_ FREGI 86_ DKPDP 91_ PTWKT 96_ RLRCA 101_ LNKSN 106_ DFEEL 111_ VERSQ 116_ LDISD 121_ PYKVY 126_ RIVPE 131_ GAKKG 136_ AKQLT 141_ LEDPQ 146_ MSMSH 151_ PYTMT 156_ TPYPS 161_ LPAQQ 166_ VHNYM 171_ MPPLD 176_ RSWRD 181_ YVPDQ 186_ PHPEI 191_ PYQCP 196_ MTFGP 201_ RGHHW 206_ QGPAC 211_ ENGCQ 216_ VTGTF 221_ YACAP 226_ PESQA 231_ PGVPT 236_ EPSIR 241_ SAEAL 246_ AFSDC 251_ RLHIC 256_ LYYRE 261_ ILVKE 266_ LTTSS 271_ PEGCR 276_ ISHGH 281_ TYDAS 286_ NLDQV 291_ LFPYP 296_ EDNGQ 301_ RKNIE 306_ KLLSH 311_ LERGV 316_ VLWMA 321_ PDGLY 326_ AKRLC 331_ QSRIY 336_ WDGPL 341_ ALCND 346_ RPNKL 351_ ERDQT 356_ CKLFD 361_ TQQFL 366_ SELQA 371_ FAHHG 376_ RSLPR 381_ FQVTL 386_ CFGEE 391_ FPDPQ 396_ RQRKL 401_ ITAHV 406_ EPLLA 411_ RQLYY 416_ FAQQN 421_ SGHFL 426_ RGYDL 431_ PEHIS 436_ NPEDY 441_ HRSIR 446_HSSIQ
1: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes