RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (EC 7.6.2.2) (EC 7.6.2.3) (Ral-interacting protein 1)
1_MTECF 6_ LPPTS 11_ SPSEH 16_ RRVEH 21_ GSGLT 26_ RTPSS 31_ EEISP 36_ TKFPG 41_ LYRTG 46_ EPSPP 51_ HDILH 56_ EPPDV 61_ VSDDE 66_ KDHGK 71_ KKGKF 76_ KKKEK 81_ RTEGY 86_ AAFQE 91_ DSSGD 96_ EAESP 101_ SKMKR 106_ SKGIH 111_ VFKKP 116_ SFSKK 121_ KEKDF 126_ KIKEK 131_ PKEEK 136_ HKEEK 141_ HKEEK 146_ HKEKK 151_ SKDLT 156_ AADVV 161_ KQWKE 166_ KKKKK 171_ KPIQE 176_ PEVPQ 181_ IDVPN 186_ LKPIF 191_ GIPLA 196_ DAVER 201_ TMMYD 206_ GIRLP 211_ AVFRE 216_ CIDYV 221_ EKYGM 226_ KCEGI 231_ YRVSG 236_ IKSKV 241_ DELKA 246_ AYDRE 251_ ESTNL 256_ EDYEP 261_ NTVAS 266_ LLKQY 271_ LRDLP 276_ ENLLT 281_ KELMP 286_ RFEEA 291_ CGRTT 296_ ETEKV 301_ QEFQR 306_ LLKEL 311_ PECNY 316_ LLISW 321_ LIVHM 326_ DHVIA 331_ KELET 336_ KMNIQ 341_ NISIV 346_ LSPTV 351_ QISNR 356_ VLYVF 361_ FTHVQ 366_ ELFGN 371_ VVLKQ 376_ VMKPL 381_ RWSNM 386_ ATMPT 391_ LPETQ 396_ AGIKE 401_ EIRRQ 406_ EFLLN 411_ CLHRD 416_ LQGGI 421_ KDLSK 426_ EERLW 431_ EVQRI 436_ LTALK 441_ RKLRE 446_ AKRQE 451_ CETKI 456_ AQEIA 461_ SLSKE 466_ DVSKE 471_ EMNEN 476_ EEVIN 481_ ILLAQ 486_ ENEIL 491_ TEQEE 496_ LLAME 501_ QFLRR 506_ QIASE 511_ KEEIE 516_ RLRAE 521_ IAEIQ 526_ SRQQH 531_ GRSET 536_ EEYSS 541_ ESESE 546_ SEDEE 551_ ELQII 556_ LEDLQ 561_ RQNEE 566_ LEIKN 571_ NHLNQ 576_ AIHEE 581_ REAII 586_ ELRVQ 591_ LRLLQ 596_ MQRAK 601_ AEQQA 606_ QEDEE 611_ PEWRG 616_ GAVQP 621_ PRDGV 626_ LEPKA 631_ AKEQP 636_ KAGKE 641_ PAKPS 646_PSRDR
1: Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle (PubMed:12775724). During mitosis, also controls mitochondrial fission as an effector of RALA (PubMed:21822277). Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (PubMed:21822277)
2: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance