Transcription factor E2F5 (E2F-5)
1_MAAAE 6_ PASSG 11_ QQAPA 16_ GQGQG 21_ QRPPP 26_ QPPQA 31_ QAPQP 36_ PPPPQ 41_ LGGAG 46_ GGSSR 51_ HEKSL 56_ GLLTT 61_ KFVSL 66_ LQEAK 71_ DGVLD 76_ LKAAA 81_ DTLAV 86_ RQKRR 91_ IYDIT 96_ NVLEG 101_ IDLIE 106_ KKSKN 111_ SIQWK 116_ GVGAG 121_ CNTKE 126_ VIDRL 131_ RYLKA 136_ EIEDL 141_ ELKER 146_ ELDQQ 151_ KLWLQ 156_ QSIKN 161_ VMDDS 166_ INNRF 171_ SYVTH 176_ EDICN 181_ CFNGD 186_ TLLAI 191_ QAPSG 196_ TQLEV 201_ PIPEM 206_ GQNGQ 211_ KKYQI 216_ NLKSH 221_ SGPIH 226_ VLLIN 231_ KESSS 236_ SKPVV 241_ FPVPP 246_ PDDLT 251_ QPSSQ 256_ SLTPV 261_ TPQKS 266_ SMATQ 271_ NLPEQ 276_ HVSER 281_ SQALQ 286_ QTSAT 291_ DISSA 296_ GSISG 301_ DIIDE 306_ LMSSD 311_ VFPLL 316_ RLSPT 321_ PADDY 326_ NFNLD 331_ DNEGV 336_ CDLFD 341_VQILN
1: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis