Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)
1_MDTGV 6_ IEGGL 11_ NVTLT 16_ IRLLM 21_ HGKEV 26_ GSIIG 31_ KKGES 36_ VKKMR 41_ EESGA 46_ RINIS 51_ EGNCP 56_ ERIIT 61_ LAGPT 66_ NAIFK 71_ AFAMI 76_ IDKLE 81_ EDISS 86_ SMTNS 91_ TAASR 96_ PPVTL 101_ RLVVP 106_ ASQCG 111_ SLIGK 116_ GGCKI 121_ KEIRE 126_ STGAQ 131_ VQVAG 136_ DMLPN 141_ STERA 146_ ITIAG 151_ IPQSI 156_ IECVK 161_ QICVV 166_ MLETL 171_ SQSPP 176_ KGVTI 181_ PYRPK 186_ PSSSP 191_ VIFAG 196_ GQDRY 201_ STGSD 206_ SASFP 211_ HTTPS 216_ MCLNP 221_ DLEGP 226_ PLEAY 231_ TIQGQ 236_ YAIPQ 241_ PDLTK 246_ LHQLA 251_ MQQSH 256_ FPMTH 261_ GNTGF 266_ SGIES 271_ SSPEV 276_ KGYWG 281_ LDASA 286_ QTTSH 291_ ELTIP 296_ NDLIG 301_ CIIGR 306_ QGAKI 311_ NEIRQ 316_ MSGAQ 321_ IKIAN 326_ PVEGS 331_ TDRQV 336_ TITGS 341_ AASIS 346_ LAQYL 351_ INVRL 356_SSETG
1: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity)
2: (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943)