Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11)
1_MVFQT 6_ RYPSW 11_ IILCY 16_ IWLLR 21_ FAHTG 26_ EAQAA 31_ KEVLL 36_ LDSKA 41_ QQTEL 46_ EWISS 51_ PPNGW 56_ EEISG 61_ LDENY 66_ TPIRT 71_ YQVCQ 76_ VMEPN 81_ QNNWL 86_ RTNWI 91_ SKGNA 96_ QRIFV 101_ ELKFT 106_ LRDCN 111_ SLPGV 116_ LGTCK 121_ ETFNL 126_ YYYET 131_ DYDTG 136_ RNIRE 141_ NLYVK 146_ IDTIA 151_ ADESF 156_ TQGDL 161_ GERKM 166_ KLNTE 171_ VREIG 176_ PLSKK 181_ GFYLA 186_ FQDVG 191_ ACIAL 196_ VSVKV 201_ YYKKC 206_ WSIIE 211_ NLAIF 216_ PDTVT 221_ GSEFS 226_ SLVEV 231_ RGTCV 236_ SSAEE 241_ EAENA 246_ PRMHC 251_ SAEGE 256_ WLVPI 261_ GKCIC 266_ KAGYQ 271_ QKGDT 276_ CEPCG 281_ RGFYK 286_ SSSQD 291_ LQCSR 296_ CPTHS 301_ FSDKE 306_ GSSRC 311_ ECEDG 316_ YYRAP 321_ SDPPY 326_ VACTR 331_ PPSAP 336_ QNLIF 341_ NINQT 346_ TVSLE 351_ WSPPA 356_ DNGGR 361_ NDVTY 366_ RILCK 371_ RCSWE 376_ QGECV 381_ PCGSN 386_ IGYMP 391_ QQTGL 396_ EDNYV 401_ TVMDL 406_ LAHAN 411_ YTFEV 416_ EAVNG 421_ VSDLS 426_ RSQRL 431_ FAAVS 436_ ITTGQ 441_ AAPSQ 446_ VSGVM 451_ KERVL 456_ QRSVE 461_ LSWQE 466_ PEHPN 471_ GVITE 476_ YEIKY 481_ YEKDQ 486_ RERTY 491_ STVKT 496_ KSTSA 501_ SINNL 506_ KPGTV 511_ YVFQI 516_ RAFTA 521_ AGYGN 526_ YSPRL 531_ DVATL 536_ EEATG 541_ KMFEA 546_ TAVSS 551_ EQNPV 556_ IIIAV 561_ VAVAG 566_ TIILV 571_ FMVFG 576_ FIIGR 581_ RHCGY 586_ SKADQ 591_ EGDEE 596_ LYFHF 601_ KFPGT 606_ KTYID 611_ PETYE 616_ DPNRA 621_ VHQFA 626_ KELDA 631_ SCIKI 636_ ERVIG 641_ AGEFG 646_ EVCSG 651_ RLKLP 656_ GKRDV 661_ AVAIK 666_ TLKVG 671_ YTEKQ 676_ RRDFL 681_ CEASI 686_ MGQFD 691_ HPNVV 696_ HLEGV 701_ VTRGK 706_ PVMIV 711_ IEFME 716_ NGALD 721_ AFLRK 726_ HDGQF 731_ TVIQL 736_ VGMLR 741_ GIAAG 746_ MRYLA 751_ DMGYV 756_ HRDLA 761_ ARNIL 766_ VNSNL 771_ VCKVS 776_ DFGLS 781_ RVIED 786_ DPEAV 791_ YTTTG 796_ GKIPV 801_ RWTAP 806_ EAIQY 811_ RKFTS 816_ ASDVW 821_ SYGIV 826_ MWEVM 831_ SYGER 836_ PYWDM 841_ SNQDV 846_ IKAIE 851_ EGYRL 856_ PAPMD 861_ CPAGL 866_ HQLML 871_ DCWQK 876_ ERAER 881_ PKFEQ 886_ IVGIL 891_ DKMIR 896_ NPNSL 901_ KTPLG 906_ TCSRP 911_ ISPLL 916_ DQNTP 921_ DFTTF 926_ CSVGE 931_ WLQAI 936_ KMERY 941_ KDNFT 946_ AAGYN 951_ SLESV 956_ ARMTI 961_ EDVMS 966_ LGITL 971_ VGHQK 976_ KIMSS 981_ IQTMR 986_ AQMLH 991_LHGTG
1: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7