Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
1_MFSFE 6_ GDFKT 11_ RPKVS 16_ LGGAS 21_ RKEEK 26_ ASLLH 31_ RTQEE 36_ RRKRE 41_ EERRR 46_ LKNAI 51_ IIQSF 56_ IRGYR 61_ DRKQQ 66_ YSIQR 71_ SAFDR 76_ CATLS 81_ QSGGA 86_ FPIAN 91_ GPNLT 96_ LLVRQ 101_ LLFFY 106_ KQNED 111_ SKRLI 116_ WLYQN 121_ LIKHS 126_ SLFVK 131_ QLDGS 136_ ERLTC 141_ LFQIK 146_ RLMSL 151_ CCRLL 156_ QNCND 161_ DSLNV 166_ ALPMR 171_ MLEVF 176_ SSENT 181_ YLPVL 186_ QDASY 191_ VVSVI 196_ EQILH 201_ YMIHN 206_ GYYRS 211_ LYLLI 216_ NSKLP 221_ SSIEY 226_ SDLSR 231_ VPIAK 236_ ILLEN 241_ VLKPL 246_ HFTYN 251_ SCPEG 256_ ARQQV 261_ FTAFT 266_ EEFLA 271_ APFTD 276_ QIFHF 281_ IIPAL 286_ ADAQT 291_ VFPYE 296_ PFLNA 301_ LLLIE 306_ SRCSR 311_ KSGGA 316_ PWLFY 321_ FVLTV 326_ GENYL 331_ GALSE 336_ EGLLV 341_ YLRVL 346_ QTFLS 351_ QLPVS 356_ PASAS 361_ CHDSA 366_ SDSEE 371_ ESEEA 376_ DKPSS 381_ PEDGR 386_ LSVSY 391_ ITEEC 396_ LKKLD 401_ TKQQT 406_ NTLLN 411_ LVWRD 416_ SASEE 421_ VFTTM 426_ ASVCH 431_ TLMVQ 436_ HRMMV 441_ PKVRL 446_ LYSLA 451_ FNARF 456_ LRHLW 461_ FLISS 466_ MSTRM 471_ ITGSM 476_ VPLLQ 481_ VISRG 486_ SPMSF 491_ EDSSR 496_ IIPLF 501_ YLFSS 506_ LFSHS 511_ LISIH 516_ DNEFF 521_ GDPIE 526_ VVGQR 531_ QSSMM 536_ PFTLE 541_ ELIML 546_ SRCLR 551_ DACLG 556_ IIKLA 561_ YPETK 566_ PEVRE 571_ EYITA 576_ FQSIG 581_ VTTSS 586_ EMQQC 591_ IQMEQ 596_ KRWIQ 601_ LFKVI 606_ TNLVK 611_ MLKSR 616_ DTRRN 621_ FCPPN 626_ HWLSE 631_ QEDIK 636_ ADKVT 641_ QLYVP 646_ ASRHV 651_ WRFRR 656_ MGRIG 661_ PLQST 666_ LDVGL 671_ ESPPL 676_ SVSEE 681_ RQLAV 686_ LTELP 691_ FVVPF 696_ EERVK 701_ IFQRL 706_ IYADK 711_ QEVQG 716_ DGPFL 721_ DGINV 726_ TIRRN 731_ YIYED 736_ AYDKL 741_ SPENE 746_ PDLKK 751_ RIRVH 756_ LLNAH 761_ GLDEA 766_ GIDGG 771_ GIFRE 776_ FLNEL 781_ LKSGF 786_ NPNQG 791_ FFKTT 796_ NEGLL 801_ YPNPA 806_ AQMLV 811_ GDSFA 816_ RHYYF 821_ LGRML 826_ GKALY 831_ ENMLV 836_ ELPFA 841_ GFFLS 846_ KLLGT 851_ SADVD 856_ IHHLA 861_ SLDPE 866_ VYKNL 871_ LFLKS 876_ YEDDV 881_ EELGL 886_ NFTVV 891_ NNDLG 896_ EAQVV 901_ ELKFG 906_ GKDIP 911_ VTSAN 916_ RIAYI 921_ HLVAD 926_ YRLNR 931_ QIRQH 936_ CLAFR 941_ QGLAN 946_ VVSLE 951_ WLRMF 956_ DQQEI 961_ QVLIS 966_ GAQVP 971_ ISLED 976_ LKSFT 981_ NYSGG 986_ YSADH 991_ PVIKV 996_ FWRVV 1001_ EGFTD 1006_ EEKRK 1011_ LLKFV 1016_ TSCSR 1021_ PPLLG 1026_ FKELY 1031_ PAFCI 1036_ HNGGS 1041_ DLERL 1046_ PTAST 1051_ CMNLL 1056_ KLPEF 1061_ YDETL 1066_ LRSKL 1071_ LYAIE 1076_CAAGF
1: E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains (PubMed:11278995, PubMed:12692129, PubMed:16341092, PubMed:16601690, PubMed:24158444, PubMed:24811749, PubMed:25752573, PubMed:25752577, PubMed:32039437, PubMed:33637724, PubMed:34239127). Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:32039437, PubMed:9575161). Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome (PubMed:24158444, PubMed:28396413, PubMed:31375563). Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins (PubMed:24811749, PubMed:31375563). Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation (PubMed:33637724). Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains; with some preference for 'Lys-48' linkages (PubMed:11278995, PubMed:16601690, PubMed:25752577). Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome (PubMed:21167755). Catalyzes ubiquitination and degradation of CAND2 (PubMed:12692129)