Angiopoietin-1 (ANG-1)
1_MTVFL 6_ SFAFL 11_ AAILT 16_ HIGCS 21_ NQRRS 26_ PENSG 31_ RRYNR 36_ IQHGQ 41_ CAYTF 46_ ILPEH 51_ DGNCR 56_ ESTTD 61_ QYNTN 66_ ALQRD 71_ APHVE 76_ PDFSS 81_ QKLQH 86_ LEHVM 91_ ENYTQ 96_ WLQKL 101_ ENYIV 106_ ENMKS 111_ EMAQI 116_ QQNAV 121_ QNHTA 126_ TMLEI 131_ GTSLL 136_ SQTAE 141_ QTRKL 146_ TDVET 151_ QVLNQ 156_ TSRLE 161_ IQLLE 166_ NSLST 171_ YKLEK 176_ QLLQQ 181_ TNEIL 186_ KIHEK 191_ NSLLE 196_ HKILE 201_ MEGKH 206_ KEELD 211_ TLKEE 216_ KENLQ 221_ GLVTR 226_ QTYII 231_ QELEK 236_ QLNRA 241_ TTNNS 246_ VLQKQ 251_ QLELM 256_ DTVHN 261_ LVNLC 266_ TKEGV 271_ LLKGG 276_ KREEE 281_ KPFRD 286_ CADVY 291_ QAGFN 296_ KSGIY 301_ TIYIN 306_ NMPEP 311_ KKVFC 316_ NMDVN 321_ GGGWT 326_ VIQHR 331_ EDGSL 336_ DFQRG 341_ WKEYK 346_ MGFGN 351_ PSGEY 356_ WLGNE 361_ FIFAI 366_ TSQRQ 371_ YMLRI 376_ ELMDW 381_ EGNRA 386_ YSQYD 391_ RFHIG 396_ NEKQN 401_ YRLYL 406_ KGHTG 411_ TAGKQ 416_ SSLIL 421_ HGADF 426_ STKDA 431_ DNDNC 436_ MCKCA 441_ LMLTG 446_ GWWFD 451_ ACGPS 456_ NLNGM 461_ FYTAG 466_ QNHGK 471_ LNGIK 476_ WHYFK 481_ GPSYS 486_ LRSTT 491_MMIRP
1: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme