Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)
1_MEPAV 6_ SLAVC 11_ ALLFL 16_ LWVRL 21_ KGLEF 26_ VLIHQ 31_ RWVFV 36_ CLFLL 41_ PLSLI 46_ FDIYY 51_ YVRAW 56_ VVFKL 61_ SSAPR 66_ LHEQR 71_ VRDIQ 76_ KQVRE 81_ WKEQG 86_ SKTFM 91_ CTGRP 96_ GWLTV 101_ SLRVG 106_ KYKKT 111_ HKNIM 116_ INLMD 121_ ILEVD 126_ TKKQI 131_ VRVEP 136_ LVTMG 141_ QVTAL 146_ LTSIG 151_ WTLPV 156_ LPELD 161_ DLTVG 166_ GLIMG 171_ TGIES 176_ SSHKY 181_ GLFQH 186_ ICTAY 191_ ELVLA 196_ DGSFV 201_ RCTPS 206_ ENSDL 211_ FYAVP 216_ WSCGT 221_ LGFLV 226_ AAEIR 231_ IIPAK 236_ KYVKL 241_ RFEPV 246_ RGLEA 251_ ICAKF 256_ THESQ 261_ RQENH 266_ FVEGL 271_ LYSLD 276_ EAVIM 281_ TGVMT 286_ DEAEP 291_ SKLNS 296_ IGNYY 301_ KPWFF 306_ KHVEN 311_ YLKTN 316_ REGLE 321_ YIPLR 326_ HYYHR 331_ HTRSI 336_ FWELQ 341_ DIIPF 346_ GNNPI 351_ FRYLF 356_ GWMVP 361_ PKISL 366_ LKLTQ 371_ GETLR 376_ KLYEQ 381_ HHVVQ 386_ DMLVP 391_ MKCLQ 396_ QALHT 401_ FQNDI 406_ HVYPI 411_ WLCPF 416_ ILPSQ 421_ PGLVH 426_ PKGNE 431_ AELYI 436_ DIGAY 441_ GEPRV 446_ KHFEA 451_ RSCMR 456_ QLEKF 461_ VRSVH 466_ GFQML 471_ YADCY 476_ MNREE 481_ FWEMF 486_ DGSLY 491_ HKLRE 496_ KLGCQ 501_ DAFPE 506_ VYDKI 511_CKAAR
1: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892)