Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)
1_MFLYN 6_ LTLQR 11_ ATGIS 16_ FAIHG 21_ NFSGT 26_ KQQEI 31_ VVSRG 36_ KILEL 41_ LRPDP 46_ NTGKV 51_ HTLLT 56_ VEVFG 61_ VIRSL 66_ MAFRL 71_ TGGTK 76_ DYIVV 81_ GSDSG 86_ RIVIL 91_ EYQPS 96_ KNMFE 101_ KIHQE 106_ TFGKS 111_ GCRRI 116_ VPGQF 121_ LAVDP 126_ KGRAV 131_ MISAI 136_ EKQKL 141_ VYILN 146_ RDAAA 151_ RLTIS 156_ SPLEA 161_ HKANT 166_ LVYHV 171_ VGVDV 176_ GFENP 181_ MFACL 186_ EMDYE 191_ EADND 196_ PTGEA 201_ AANTQ 206_ QTLTF 211_ YELDL 216_ GLNHV 221_ VRKYS 226_ EPLEE 231_ HGNFL 236_ ITVPG 241_ GSDGP 246_ SGVLI 251_ CSENY 256_ ITYKN 261_ FGDQP 266_ DIRCP 271_ IPRRR 276_ NDLDD 281_ PERGM 286_ IFVCS 291_ ATHKT 296_ KSMFF 301_ FLAQT 306_ EQGDI 311_ FKITL 316_ ETDED 321_ MVTEI 326_ RLKYF 331_ DTVPV 336_ AAAMC 341_ VLKTG 346_ FLFVA 351_ SEFGN 356_ HYLYQ 361_ IAHLG 366_ DDDEE 371_ PEFSS 376_ AMPLE 381_ EGDTF 386_ FFQPR 391_ PLKNL 396_ VLVDE 401_ LDSLS 406_ PILFC 411_ QIADL 416_ ANEDT 421_ PQLYV 426_ ACGRG 431_ PRSSL 436_ RVLRH 441_ GLEVS 446_ EMAVS 451_ ELPGN 456_ PNAVW 461_ TVRRH 466_ IEDEF 471_ DAYII 476_ VSFVN 481_ ATLVL 486_ SIGET 491_ VEEVT 496_ DSGFL 501_ GTTPT 506_ LSCSL 511_ LGDDA 516_ LVQVY 521_ PDGIR 526_ HIRAD 531_ KRVNE 536_ WKTPG 541_ KKTIV 546_ KCAVN 551_ QRQVV 556_ IALTG 561_ GELVY 566_ FEMDP 571_ SGQLN 576_ EYTER 581_ KEMSA 586_ DVVCM 591_ SLANV 596_ PPGEQ 601_ RSRFL 606_ AVGLV 611_ DNTVR 616_ IISLD 621_ PSDCL 626_ QPLSM 631_ QALPA 636_ QPESL 641_ CIVEM 646_ GGTEK 651_ QDELG 656_ ERGSI 661_ GFLYL 666_ NIGLQ 671_ NGVLL 676_ RTVLD 681_ PVTGD 686_ LSDTR 691_ TRYLG 696_ SRPVK 701_ LFRVR 706_ MQGQE 711_ AVLAM 716_ SSRSW 721_ LSYSY 726_ QSRFH 731_ LTPLS 736_ YETLE 741_ FASGF 746_ ASEQC 751_ PEGIV 756_ AISTN 761_ TLRIL 766_ ALEKL 771_ GAVFN 776_ QVAFP 781_ LQYTP 786_ RKFVI 791_ HPESN 796_ NLIII 801_ ETDHN 806_ AYTEA 811_ TKAQR 816_ KQQMA 821_ EEMVE 826_ AAGED 831_ ERELA 836_ AEMAA 841_ AFLNE 846_ NLPES 851_ IFGAP 856_ KAGNG 861_ QWASV 866_ IRVMN 871_ PIQGN 876_ TLDLV 881_ QLEQN 886_ EAAFS 891_ VAVCR 896_ FSNTG 901_ EDWYV 906_ LVGVA 911_ KDLIL 916_ NPRSV 921_ AGGFV 926_ YTYKL 931_ VNNGE 936_ KLEFL 941_ HKTPV 946_ EEVPA 951_ AIAPF 956_ QGRVL 961_ IGVGK 966_ LLRVY 971_ DLGKK 976_ KLLRK 981_ CENKH 986_ IANYI 991_ SGIQT 996_ IGHRV 1001_ IVSDV 1006_ QESFI 1011_ WVRYK 1016_ RNENQ 1021_ LIIFA 1026_ DDTYP 1031_ RWVTT 1036_ ASLLD 1041_ YDTVA 1046_ GADKF 1051_ GNICV 1056_ VRLPP 1061_ NTNDE 1066_ VDEDP 1071_ TGNKA 1076_ LWDRG 1081_ LLNGA 1086_ SQKAE 1091_ VIMNY 1096_ HVGET 1101_ VLSLQ 1106_ KTTLI 1111_ PGGSE 1116_ SLVYT 1121_ TLSGG 1126_ IGILV 1131_ PFTSH 1136_ EDHDF 1141_ FQHVE 1146_ MHLRS 1151_ EHPPL 1156_ CGRDH 1161_ LSFRS 1166_ YYFPV 1171_ KNVID 1176_ GDLCE 1181_ QFNSM 1186_ EPNKQ 1191_ KNVSE 1196_ ELDRT 1201_ PPEVS 1206_ KKLED 1211_IRTRY
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10490618, PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (PubMed:12234937, PubMed:27720643). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077, PubMed:33509932)