Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
1_MTSIF 6_ HFAII 11_ FMLIL 16_ QIRIQ 21_ LSEES 26_ EFLVD 31_ RSKNG 36_ LIHVP 41_ KDLSQ 46_ KTTIL 51_ NISQN 56_ YISEL 61_ WTSDI 66_ LSLSK 71_ LRILI 76_ ISHNR 81_ IQYLD 86_ ISVFK 91_ FNQEL 96_ EYLDL 101_ SHNKL 106_ VKISC 111_ HPTVN 116_ LKHLD 121_ LSFNA 126_ FDALP 131_ ICKEF 136_ GNMSQ 141_ LKFLG 146_ LSTTH 151_ LEKSS 156_ VLPIA 161_ HLNIS 166_ KVLLV 171_ LGETY 176_ GEKED 181_ PEGLQ 186_ DFNTE 191_ SLHIV 196_ FPTNK 201_ EFHFI 206_ LDVSV 211_ KTVAN 216_ LELSN 221_ IKCVL 226_ EDNKC 231_ SYFLS 236_ ILAKL 241_ QTNPK 246_ LSNLT 251_ LNNIE 256_ TTWNS 261_ FIRIL 266_ QLVWH 271_ TTVWY 276_ FSISN 281_ VKLQG 286_ QLDFR 291_ DFDYS 296_ GTSLK 301_ ALSIH 306_ QVVSD 311_ VFGFP 316_ QSYIY 321_ EIFSN 326_ MNIKN 331_ FTVSG 336_ TRMVH 341_ MLCPS 346_ KISPF 351_ LHLDF 356_ SNNLL 361_ TDTVF 366_ ENCGH 371_ LTELE 376_ TLILQ 381_ MNQLK 386_ ELSKI 391_ AEMTT 396_ QMKSL 401_ QQLDI 406_ SQNSV 411_ SYDEK 416_ KGDCS 421_ WTKSL 426_ LSLNM 431_ SSNIL 436_ TDTIF 441_ RCLPP 446_ RIKVL 451_ DLHSN 456_ KIKSI 461_ PKQVV 466_ KLEAL 471_ QELNV 476_ AFNSL 481_ TDLPG 486_ CGSFS 491_ SLSVL 496_ IIDHN 501_ SVSHP 506_ SADFF 511_ QSCQK 516_ MRSIK 521_ AGDNP 526_ FQCTC 531_ ELGEF 536_ VKNID 541_ QVSSE 546_ VLEGW 551_ PDSYK 556_ CDYPE 561_ SYRGT 566_ LLKDF 571_ HMSEL 576_ SCNIT 581_ LLIVT 586_ IVATM 591_ LVLAV 596_ TVTSL 601_ CSYLD 606_ LPWYL 611_ RMVCQ 616_ WTQTR 621_ RRARN 626_ IPLEE 631_ LQRNL 636_ QFHAF 641_ ISYSG 646_ HDSFW 651_ VKNEL 656_ LPNLE 661_ KEGMQ 666_ ICLHE 671_ RNFVP 676_ GKSIV 681_ ENIIT 686_ CIEKS 691_ YKSIF 696_ VLSPN 701_ FVQSE 706_ WCHYE 711_ LYFAH 716_ HNLFH 721_ EGSNS 726_ LILIL 731_ LEPIP 736_ QYSIP 741_ SSYHK 746_ LKSLM 751_ ARRTY 756_ LEWPK 761_ EKSKR 766_ GLFWA 771_ NLRAA 776_ INIKL 781_TEQAK
1: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response