Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
1_MPLAQ 6_ LKEPW 11_ PLMEL 16_ VPLDP 21_ ENGQT 26_ SGEEA 31_ GLQPS 36_ KDEGV 41_ LKEIS 46_ ITHHV 51_ KAGSE 56_ KADPS 61_ HFELL 66_ KVLGQ 71_ GSFGK 76_ VFLVR 81_ KVTRP 86_ DSGHL 91_ YAMKV 96_ LKKAT 101_ LKVRD 106_ RVRTK 111_ MERDI 116_ LADVN 121_ HPFVV 126_ KLHYA 131_ FQTEG 136_ KLYLI 141_ LDFLR 146_ GGDLF 151_ TRLSK 156_ EVMFT 161_ EEDVK 166_ FYLAE 171_ LALGL 176_ DHLHS 181_ LGIIY 186_ RDLKP 191_ ENILL 196_ DEEGH 201_ IKLTD 206_ FGLSK 211_ EAIDH 216_ EKKAY 221_ SFCGT 226_ VEYMA 231_ PEVVN 236_ RQGHS 241_ HSADW 246_ WSYGV 251_ LMFEM 256_ LTGSL 261_ PFQGK 266_ DRKET 271_ MTLIL 276_ KAKLG 281_ MPQFL 286_ STEAQ 291_ SLLRA 296_ LFKRN 301_ PANRL 306_ GSGPD 311_ GAEEI 316_ KRHVF 321_ YSTID 326_ WNKLY 331_ RREIK 336_ PPFKP 341_ AVAQP 346_ DDTFY 351_ FDTEF 356_ TSRTP 361_ KDSPG 366_ IPPSA 371_ GAHQL 376_ FRGFS 381_ FVATG 386_ LMEDD 391_ GKPRA 396_ PQAPL 401_ HSVVQ 406_ QLHGK 411_ NLVFS 416_ DGYVV 421_ KETIG 426_ VGSYS 431_ ECKRC 436_ VHKAT 441_ NMEYA 446_ VKVID 451_ KSKRD 456_ PSEEI 461_ EILLR 466_ YGQHP 471_ NIITL 476_ KDVYD 481_ DGKHV 486_ YLVTE 491_ LMRGG 496_ ELLDK 501_ ILRQK 506_ FFSER 511_ EASFV 516_ LHTIG 521_ KTVEY 526_ LHSQG 531_ VVHRD 536_ LKPSN 541_ ILYVD 546_ ESGNP 551_ ECLRI 556_ CDFGF 561_ AKQLR 566_ AENGL 571_ LMTPC 576_ YTANF 581_ VAPEV 586_ LKRQG 591_ YDEGC 596_ DIWSL 601_ GILLY 606_ TMLAG 611_ YTPFA 616_ NGPSD 621_ TPEEI 626_ LTRIG 631_ SGKFT 636_ LSGGN 641_ WNTVS 646_ ETAKD 651_ LVSKM 656_ LHVDP 661_ HQRLT 666_ AKQVL 671_ QHPWV 676_ TQKDK 681_ LPQSQ 686_ LSHQD 691_ LQLVK 696_ GAMAA 701_ TYSAL 706_ NSSKP 711_ TPQLK 716_ PIESS 721_ ILAQR 726_RVRKL
1: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:12213813, PubMed:15117958, PubMed:16223362, PubMed:17360704, PubMed:18722121, PubMed:26158630, PubMed:35772404, PubMed:9430688). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404)
2: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated