Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)
1_MDFQH 6_ RPGGK 11_ TGSGG 16_ VASSS 21_ ESNRD 26_ RRERL 31_ RQLAL 36_ ETIDI 41_ NKDPY 46_ FMKNH 51_ LGSYE 56_ CKLCL 61_ TLHNN 66_ EGSYL 71_ AHTQG 76_ KKHQT 81_ NLARR 86_ AAKEA 91_ KEAPA 96_ QPAPE 101_ KVKVE 106_ VKKFV 111_ KIGRP 116_ GYKVT 121_ KQRDS 126_ EMGQQ 131_ SLLFQ 136_ IDYPE 141_ IAEGI 146_ MPRHR 151_ FMSAY 156_ EQRIE 161_ PPDRR 166_ WQYLL 171_ MAAEP 176_ YETIA 181_ FKVPS 186_ REIDK 191_ AEGKF 196_ WTHWN 201_ RETKQ 206_ FFLQF 211_ HFKME 216_ KPPAP 221_ PSLPA 226_ GPPGV 231_ KRPPP 236_ PLMNG 241_ LPPRP 246_ PLPES 251_ LPPPP 256_ PGGLP 261_ LPPMP 266_ PTGPA 271_ PSGPP 276_ GPPQL 281_ PPPAP 286_ GVHPP 291_ APVVH 296_ PPASG 301_ VHPPA 306_ PGVHP 311_ PAPGV 316_ HPPAP 321_ GVHPP 326_ TSGVH 331_ PPAPG 336_ VHPPA 341_ PGVHP 346_ PAPGV 351_ HPPAP 356_ GVHPP 361_ APGVH 366_ PPPSA 371_ GVHPQ 376_ APGVH 381_ PAAPA 386_ VHPQA 391_ PGVHP 396_ PAPGM 401_ HPQAP 406_ GVHPQ 411_ PPGVH 416_ PSAPG 421_ VHPQP 426_ PGVHP 431_ SNPGV 436_ HPPTP 441_ MPPML 446_ RPPLP 451_ SEGPG 456_NIPPP
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106)