Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)
1_MEEDD 6_ SYVPS 11_ DLTAE 16_ ERQEL 21_ ENIRR 26_ RKQEL 31_ LADIQ 36_ RLKDE 41_ IAEVA 46_ NEIEN 51_ LGSTE 56_ ERKNM 61_ QRNKQ 66_ VAMGR 71_ KKFNM 76_ DPKKG 81_ IQFLI 86_ ENDLL 91_ KNTCE 96_ DIAQF 101_ LYKGE 106_ GLNKT 111_ AIGDY 116_ LGERD 121_ EFNIQ 126_ VLHAF 131_ VELHE 136_ FTDLN 141_ LVQAL 146_ RQFLW 151_ SFRLP 156_ GEAQK 161_ IDRMM 166_ EAFAQ 171_ RYCQC 176_ NNGVF 181_ QSTDT 186_ CYVLS 191_ FAIIM 196_ LNTSL 201_ HNPNV 206_ KDKPT 211_ VERFI 216_ AMNRG 221_ INDGG 226_ DLPEE 231_ LLRNL 236_ YESIK 241_ NEPFK 246_ IPEDD 251_ GNDLT 256_ HTFFN 261_ PDREG 266_ WLLKL 271_ GGGRV 276_ KTWKR 281_ RWFIL 286_ TDNCL 291_ YYFEY 296_ TTDKE 301_ PRGII 306_ PLENL 311_ SIREV 316_ EDSKK 321_ PNCFE 326_ LYIPD 331_ NKDQV 336_ IKACK 341_ TEADG 346_ RVVEG 351_ NHTVY 356_ RISAP 361_ TPEEK 366_ EEWIK 371_ CIKAA 376_ ISRDP 381_ FYEML 386_ AARKK 391_KVSST
1: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity