Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)
1_MPAGP 6_ VQAVP 11_ PPPPV 16_ PTEPK 21_ QPTEE 26_ EASSK 31_ EDSAP 36_ SKPVV 41_ GIIYP 46_ PPEVR 51_ NIVDK 56_ TASFV 61_ ARNGP 66_ EFEAR 71_ IRQNE 76_ INNPK 81_ FNFLN 86_ PNDPY 91_ HAYYR 96_ HKVSE 101_ FKEGK 106_ AQEPS 111_ AAIPK 116_ VMQQQ 121_ QQTTQ 126_ QQLPQ 131_ KVQAQ 136_ VIQET 141_ IVPKE 146_ PPPEF 151_ EFIAD 156_ PPSIS 161_ AFDLD 166_ VVKLT 171_ AQFVA 176_ RNGRQ 181_ FLTQL 186_ MQKEQ 191_ RNYQF 196_ DFLRP 201_ QHSLF 206_ NYFTK 211_ LVEQY 216_ TKILI 221_ PPKGL 226_ FSKLK 231_ KEAEN 236_ PREVL 241_ DQVCY 246_ RVEWA 251_ KFQER 256_ ERKKE 261_ EEEKE 266_ KERVA 271_ YAQID 276_ WHDFV 281_ VVETV 286_ DFQPN 291_ EQGNF 296_ PPPTT 301_ PEELG 306_ ARILI 311_ QERYE 316_ KFGES 321_ EEVEM 326_ EVESD 331_ EEDDK 336_ QEKAE 341_ EPPSQ 346_ LDQDT 351_ QVQDM 356_ DEGSD 361_ DEEEG 366_ QKVPP 371_ PPETP 376_ MPPPL 381_ PPTPD 386_ QVIVR 391_ KDYDP 396_ KASKP 401_ LPPAP 406_ APDEY 411_ LVSPI 416_ TGEKI 421_ PASKM 426_ QEHMR 431_ IGLLD 436_ PRWLE 441_ QRDRS 446_ IREKQ 451_ SDDEV 456_ YAPGL 461_ DIESS 466_ LKQLA 471_ ERRTD 476_ IFGVE 481_ ETAIG 486_ KKIGE 491_ EEIQK 496_ PEEKV 501_ TWDGH 506_ SGSMA 511_ RTQQA 516_ AQANI 521_ TLQEQ 526_ IEAIH 531_ KAKGL 536_ VPEDD 541_ TKEKI 546_ GPSKP 551_ NEIPQ 556_ QPPPP 561_ SSATN 566_ IPSSA 571_ PPITS 576_ VPRPP 581_ TMPPP 586_ VRTTV 591_ VSAVP 596_ VMPRP 601_ PMASV 606_ VRLPP 611_ GSVIA 616_ PMPPI 621_ IHAPR 626_ INVVP 631_ MPPSA 636_ PPIMA 641_ PRPPP 646_ MIVPT 651_ AFVPA 656_ PPVAP 661_ VPAPA 666_ PMPPV 671_ HPPPP 676_ MEDEP 681_ TSKKL 686_ KTEDS 691_ LMPEE 696_ EFLRR 701_ NKGPV 706_ SIKVQ 711_ VPNMQ 716_ DKTEW 721_ KLNGQ 726_ VLVFT 731_ LPLTD 736_ QVSVI 741_ KVKIH 746_ EATGM 751_ PAGKQ 756_ KLQYE 761_ GIFIK 766_ DSNSL 771_ AYYNM 776_ ANGAV 781_ IHLAL 786_KERGG
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006). Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes (PubMed:29360106, PubMed:30315277)