Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
1_MLLLA 6_ RCLLL 11_ VLVSS 16_ LLVCS 21_ GLACG 26_ PGRGF 31_ GKRRH 36_ PKKLT 41_ PLAYK 46_ QFIPN 51_ VAEKT 56_ LGASG 61_ RYEGK 66_ ISRNS 71_ ERFKE 76_ LTPNY 81_ NPDII 86_ FKDEE 91_ NTGAD 96_ RLMTQ 101_ RCKDK 106_ LNALA 111_ ISVMN 116_ QWPGV 121_ KLRVT 126_ EGWDE 131_ DGHHS 136_ EESLH 141_ YEGRA 146_ VDITT 151_ SDRDR 156_ SKYGM 161_ LARLA 166_ VEAGF 171_ DWVYY 176_ ESKAH 181_ IHCSV 186_ KAENS 191_ VAAKS 196_ GGCFP 201_ GSATV 206_ HLEQG 211_ GTKLV 216_ KDLSP 221_ GDRVL 226_ AADDQ 231_ GRLLY 236_ SDFLT 241_ FLDRD 246_ DGAKK 251_ VFYVI 256_ ETREP 261_ RERLL 266_ LTAAH 271_ LLFVA 276_ PHNDS 281_ ATGEP 286_ EASSG 291_ SGPPS 296_ GGALG 301_ PRALF 306_ ASRVR 311_ PGQRV 316_ YVVAE 321_ RDGDR 326_ RLLPA 331_ AVHSV 336_ TLSEE 341_ AAGAY 346_ APLTA 351_ QGTIL 356_ INRVL 361_ ASCYA 366_ VIEEH 371_ SWAHR 376_ AFAPF 381_ RLAHA 386_ LLAAL 391_ APART 396_ DRGGD 401_ SGGGD 406_ RGGGG 411_ GRVAL 416_ TAPGA 421_ ADAPG 426_ AGATA 431_ GIHWY 436_ SQLLY 441_ QIGTW 446_ LLDSE 451_ ALHPL 456_GMAVK
1: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the endoplasmic reticulum (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity)
2: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:10753901). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (PubMed:10753901)