Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)
1_MSTSQ 6_ PGACP 11_ CQGAA 16_ SRPAI 21_ LYALL 26_ SSSLK 31_ AVPRP 36_ RSRCL 41_ CRQHR 46_ PVQLC 51_ APHRT 56_ CREAL 61_ DVLAK 66_ TVAFL 71_ RNLPS 76_ FWQLP 81_ PQDQR 86_ RLLQG 91_ CWGPL 96_ FLLGL 101_ AQDAV 106_ TFEVA 111_ EAPVP 116_ SILKK 121_ ILLEE 126_ PSSSG 131_ GSGQL 136_ PDRPQ 141_ PSLAA 146_ VQWLQ 151_ CCLES 156_ FWSLE 161_ LSPKE 166_ YACLK 171_ GTILF 176_ NPDVP 181_ GLQAA 186_ SHIGH 191_ LQQEA 196_ HWVLC 201_ EVLEP 206_ WCPAA 211_ QGRLT 216_ RVLLT 221_ ASTLK 226_ SIPTS 231_ LLGDL 236_ FFRPI 241_ IGDVD 246_ IAGLL 251_GDMLL
1: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:22504882). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:22504882). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity)