Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
1_MSMLP 6_ SFGFT 11_ QEQVA 16_ CVCEV 21_ LQQGG 26_ NLERL 31_ GRFLW 36_ SLPAC 41_ DHLHK 46_ NESVL 51_ KAKAV 56_ VAFHR 61_ GNFRE 66_ LYKIL 71_ ESHQF 76_ SPHNH 81_ PKLQQ 86_ LWLKA 91_ HYVEA 96_ EKLRG 101_ RPLGA 106_ VGKYR 111_ VRRKF 116_ PLPRT 121_ IWDGE 126_ ETSYC 131_ FKEKS 136_ RGVLR 141_ EWYAH 146_ NPYPS 151_ PREKR 156_ ELAEA 161_ TGLTT 166_ TQVSN 171_ WFKNR 176_ RQRDR 181_ AAEAK 186_ ERENT 191_ ENNNS 196_ SSNKQ 201_ NQLSP 206_ LEGGK 211_ PLMSS 216_ SEEEF 221_ SPPQS 226_ PDQNS 231_ VLLLQ 236_ GNMGH 241_ ARSSN 246_ YSLPG 251_ LTASQ 256_ PSHGL 261_ QTHQH 266_ QLQDS 271_ LLGPL 276_TSSLV
1: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity). Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity). Depending on context, functions as a transcriptional repressor or activator (By similarity). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:15141091, PubMed:19497856, PubMed:23435380, PubMed:27923061). Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity). During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1 (PubMed:15123840). Promotes brown adipocyte differentiation (By similarity)