Helicase SKI2W (Ski2) (EC 3.6.4.-) (Helicase-like protein) (HLP)
1_MMETE 6_ RLVLP 11_ PPDPL 16_ DLPLR 21_ AVELG 26_ CTGHW 31_ ELLNL 36_ PGAPE 41_ SSLPH 46_ GLPPC 51_ APDLQ 56_ QEAEQ 61_ LFLSS 66_ PAWLP 71_ LHGVE 76_ HSARK 81_ WQRKT 86_ DPWSL 91_ LAVLG 96_ APVPS 101_ DLQAQ 106_ RHPTT 111_ GQILG 116_ YKEVL 121_ LENTN 126_ LSATT 131_ SLSLR 136_ RPPGP 141_ ASQSL 146_ WGNPT 151_ QYPFW 156_ PGGMD 161_ EPTIT 166_ DLNTR 171_ EEAEE 176_ EIDFE 181_ KDLLT 186_ IPPGF 191_ KKGMD 196_ FAPKD 201_ CPTPA 206_ PGLLS 211_ LSCML 216_ EPLDL 221_ GGGDE 226_ DENEA 231_ VGQPG 236_ GPRGD 241_ TVSAS 246_ PCSAP 251_ LARAS 256_ SLEDL 261_ VLKEA 266_ STAVS 271_ TPEAP 276_ EPPSQ 281_ EQWAI 286_ PVDAT 291_ SPVGD 296_ FYRLI 301_ PQPAF 306_ QWAFE 311_ PDVFQ 316_ KQAIL 321_ HLERH 326_ DSVFV 331_ AAHTS 336_ AGKTV 341_ VAEYA 346_ IALAQ 351_ KHMTR 356_ TIYTS 361_ PIKAL 366_ SNQKF 371_ RDFRN 376_ TFGDV 381_ GLLTG 386_ DVQLH 391_ PEASC 396_ LIMTT 401_ EILRS 406_ MLYSG 411_ SDVIR 416_ DLEWV 421_ IFDEV 426_ HYIND 431_ VERGV 436_ VWEEV 441_ LIMLP 446_ DHVSI 451_ ILLSA 456_ TVPNA 461_ LEFAD 466_ WIGRL 471_ KRRQI 476_ YVIST 481_ VTRPV 486_ PLEHY 491_ LFTGN 496_ SSKTQ 501_ GELFL 506_ LLDSR 511_ GAFHT 516_ KGYYA 521_ AVEAK 526_ KERMS 531_ KHAQT 536_ FGAKQ 541_ PTHQG 546_ GPAQD 551_ RGVYL 556_ SLLAS 561_ LRTRA 566_ QLPVV 571_ VFTFS 576_ RGRCD 581_ EQASG 586_ LTSLD 591_ LTTSS 596_ EKSEI 601_ HLFLQ 606_ RCLAR 611_ LRGSD 616_ RQLPQ 621_ VLHMS 626_ ELLNR 631_ GLGVH 636_ HSGIL 641_ PILKE 646_ IVEML 651_ FSRGL 656_ VKVLF 661_ ATETF 666_ AMGVN 671_ MPART 676_ VVFDS 681_ MRKHD 686_ GSTFR 691_ DLLPG 696_ EYVQM 701_ AGRAG 706_ RRGLD 711_ PTGTV 716_ ILLCK 721_ GRVPE 726_ MADLH 731_ RMMMG 736_ KPSQL 741_ QSQFR 746_ LTYTM 751_ ILNLL 756_ RVDAL 761_ RVEDM 766_ MKRSF 771_ SEFPS 776_ RKDSK 781_ AHEQA 786_ LAELT 791_ KRLGA 796_ LEEPD 801_ MTGQL 806_ VDLPE 811_ YYSWG 816_ EELTE 821_ TQHMI 826_ QRRIM 831_ ESVNG 836_ LKSLS 841_ AGRVV 846_ VVKNQ 851_ EHHNA 856_ LGVIL 861_ QVSSN 866_ STSRV 871_ FTTLV 876_ LCDKP 881_ LSQDP 886_ QDRGP 891_ ATAEV 896_ PYPDD 901_ LVGFK 906_ LFLPE 911_ GPCDH 916_ TVVKL 921_ QPGDM 926_ AAITT 931_ KVLRV 936_ NGEKI 941_ LEDFS 946_ KRQQP 951_ KFKKD 956_ PPLAA 961_ VTTAV 966_ QELLR 971_ LAQAH 976_ PAGPP 981_ TLDPV 986_ NDLQL 991_ KDMSV 996_ VEGGL 1001_ RARKL 1006_ EELIQ 1011_ GAQCV 1016_ HSPRF 1021_ PAQYL 1026_ KLRER 1031_ MQIQK 1036_ EMERL 1041_ RFLLS 1046_ DQSLL 1051_ LLPEY 1056_ HQRVE 1061_ VLRTL 1066_ GYVDE 1071_ AGTVK 1076_ LAGRV 1081_ ACAMS 1086_ SHELL 1091_ LTELM 1096_ FDNAL 1101_ STLRP 1106_ EEIAA 1111_ LLSGL 1116_ VCQSP 1121_ GDAGD 1126_ QLPNT 1131_ LKQGI 1136_ ERVRA 1141_ VAKRI 1146_ GEVQV 1151_ ACGLN 1156_ QTVEE 1161_ FVGEL 1166_ NFGLV 1171_ EVVYE 1176_ WARGM 1181_ PFSEL 1186_ AGLSG 1191_ TPEGL 1196_ VVRCI 1201_ QRLAE 1206_ MCRSL 1211_ RGAAR 1216_ LVGEP 1221_ VLGAK 1226_ METAA 1231_ TLLRR 1236_ DIVFA 1241_ASLYT
1: Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656)